Pediatric Research Centers

Investigators in the Department of Pediatrics at Washington University hold many NIH-supported grants. Larger, multidisciplinary projects include:

Washington University Intellectual and Developmental Disability Research Center (WUIDDRC)

The Washington University Intellectual and Developmental Disability Research Center (WUIDDRC) is the latest center to receive funding in order to expand the Centers of Excellence for research in mental retardation and developmental disabilities established by Congress in 1963.  The IDDRCs are the nation’s first and foremost sustained effort to prevent and treat developmental disabilities through biomedical and behavioral research.  The mission of the WUIDDRC is to promote cutting-edge innovation in research related to developmental disabilities.  It incorporates a mechanism for effective, regular and vigorous communication coordination with scientists in other organizations, clinical providers for children with developmental disabilities and the local community.  We seek to focus a wealth of talent on intellectual and developmental disabilities and stimulate advances by creating collaborative, interdisciplinary environment that will augment research and clinical care to improve the lives of children with developmental disabilities.  More information is available on the WUIDDRC website.  The Program Director/Principal Investigators for this project are Drs. John Constantino and Bradley Schlaggar.

Child Health Research Center

The Department of Pediatrics at Washington University School of Medicine recently received a five-year, $2 million renewal of its designation as a Child Health Research Center of Excellence by the National Institutes of Health.  Work in this Center focuses on human developmental biology, promoting discovery by junior Pediatrics faculty in the pathology of, and novel treatments for, a spectrum of pediatric diseases and conditions.  The principal investigator for this project is Dr. Gary Silverman, and the program director is Dr. David Hunstad.


The Department of Pediatrics recently received a five-year, $7.8 million grant to address a major question in transfusion medicine and pediatric critical care. "Does the transfusion of RBCs of decreased storage duration improve outcomes in critically ill patients?”  ABC-PICU is a multi-center, international, pragmatic, double-blind, randomized clinical trial comparing the risk of New or Progressive Multiple Organ Dysfunction Syndrome (NPMODS) between critically ill children transfused red blood cells (RBCs) of decreased storage age and those transfused standard issue RBCs. The principal investigator for this project is Dr. Phil Spinella.