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Pediatric Research >> Thomas Ferkol's Lab >> Home Home Personnel Projects Publications Investigator Biography   Ferkol Lab Dr. Ferkol’s research has focused on the development of cell and animal models to study cystic fibrosis, defining genetic and molecular factors that contribute to airway infection, inflammation, and injury.  He has used these models to examine the effects of bacterium-epithelium interaction in the CF airway and study non-invasive measures of inflammation in the cystic fibrosis lung.  With funding from the National Institutes of Health (NIH) and Cystic Fibrosis Foundation, he and his collaborators have also developed novel approaches for airway-specific drug delivery.  These approaches could provide better assessment tools and novel treatment strategies for suppurative lung diseases in children. More recently, his laboratory has turned its efforts to another airway disease, primary ciliary dyskinesia, a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Ferkol serves as an investigator for the NIH-supported Genetic Diseases of Mucociliary Clearance Consortium, a clinical research network to study rare diseases of the airways. He has also formed a multidisciplinary research collaborative that defines clinical, functional, and structural phenotypes of patient subpopulations with known or suspected ciliopathies, a project funded by the Children’s Discovery Institute.  Dr. Ferkol has assembled clinical and scientific expertise from across both university campuses that are studying the genetic and phenotypic spectrum of ciliopathies, which should lead to improved standards for diagnosis, clinical care, and identification of better therapeutic approaches.   Related Links Division of Pediatric Allergy and Pulmonary Medicine Division of Pediatric Allergy and Pulmonary Medicine fellowship program Research at Washington University in St Louis Contact Information Thomas W. Ferkol, M.D. Department of Pediatrics Division of Pediatric Allergy and Pulmonary Medicine at St Louis Children’s Hospital Washington University School of Medicine 4905 Children’s Place, Box 8116 St. Louis, Missouri 63110 e-mail address: ferkol_t@kids.wustl.edu Ferkol Lab Dr. Ferkol’s research has focused on the development of cell and animal models to study cystic fibrosis, defining genetic and molecular factors that contribute to airway infection, inflammation, and injury.  He has used these models to examine the effects of bacterium-epithelium interaction in the CF airway and study non-invasive measures of inflammation in the cystic fibrosis lung.  With funding from the National Institutes of Health (NIH) and Cystic Fibrosis Foundation, he and his collaborators have also developed novel approaches for airway-specific drug delivery.  These approaches could provide better assessment tools and novel treatment strategies for suppurative lung diseases in children. More recently, his laboratory has turned its efforts to another airway disease, primary ciliary dyskinesia, a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Ferkol serves as an investigator for the NIH-supported Genetic Diseases of Mucociliary Clearance Consortium, a clinical research network to study rare diseases of the airways. He has also formed a multidisciplinary research collaborative that defines clinical, functional, and structural phenotypes of patient subpopulations with known or suspected ciliopathies, a project funded by the Children’s Discovery Institute.  Dr. Ferkol has assembled clinical and scientific expertise from across both university campuses that are studying the genetic and phenotypic spectrum of ciliopathies, which should lead to improved standards for diagnosis, clinical care, and identification of better therapeutic approaches.   Related Links Division of Pediatric Allergy and Pulmonary Medicine Division of Pediatric Allergy and Pulmonary Medicine fellowship program Research at Washington University in St Louis Contact Information Thomas W. Ferkol, M.D. Department of Pediatrics Division of Pediatric Allergy and Pulmonary Medicine at St Louis Children’s Hospital Washington University School of Medicine 4905 Children’s Place, Box 8116 St. Louis, Missouri 63110 e-mail address: ferkol_t@kids.wustl.edu

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