Hunstad Lab
Our lab focuses primarily on the interactions of pathogenic Gram-negative bacteria with their hosts. In particular, we aim to elucidate the modulation of host immune responses by pathogens and to determine the mechanisms by which these bacteria present specific virulence factors on their surfaces.
Currently, we are studying the molecular mechanisms by which conserved periplasmic chaperones, such as SurA, contribute to the assembly and presentation of surface virulence factors by Gram-negative pathogens. Specifically, we are identifying SurA-dependent outer membrane proteins of E. coli that contribute to the pathogenesis of urinary tract infections.
In addition, we are using cultured bladder epithelial cells and the murine model of cystitis to investigate the ability of uropathogenic E. coli to modulate host innate and adaptive immune responses. Our goal is to discover novel targets for interventions that will prevent and treat Gram-negative infections of the urinary tract, gastrointestinal tract, and central nervous system. Along these lines, we are also using recent discoveries in UTI pathogenesis to design nanoparticle-based therapies for prevention of acute and recurrent UTI.
Finally, we participate in collaborative, translational studies of pediatric infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).
Our lab is part of the Pathobiology Research Unit in the Department of Pediatrics. It is located on the 6th floor of the McDonnell Pediatric Research Building.
Links
Division of Pediatric Infectious Diseases
Pediatric Infectious Diseases Fellowship Program
Hunstad Lab
Our lab focuses primarily on the interactions of pathogenic Gram-negative bacteria with their hosts. In particular, we aim to elucidate the modulation of host immune responses by pathogens and to determine the mechanisms by which these bacteria present specific virulence factors on their surfaces.
Currently, we are studying the molecular mechanisms by which conserved periplasmic chaperones, such as SurA, contribute to the assembly and presentation of surface virulence factors by Gram-negative pathogens. Specifically, we are identifying SurA-dependent outer membrane proteins of E. coli that contribute to the pathogenesis of urinary tract infections.
In addition, we are using cultured bladder epithelial cells and the murine model of cystitis to investigate the ability of uropathogenic E. coli to modulate host innate and adaptive immune responses. Our goal is to discover novel targets for interventions that will prevent and treat Gram-negative infections of the urinary tract, gastrointestinal tract, and central nervous system. Along these lines, we are also using recent discoveries in UTI pathogenesis to design nanoparticle-based therapies for prevention of acute and recurrent UTI.
Finally, we participate in collaborative, translational studies of pediatric infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).
Our lab is part of the Pathobiology Research Unit in the Department of Pediatrics. It is located on the 6th floor of the McDonnell Pediatric Research Building.
Links
Division of Pediatric Infectious Diseases
Pediatric Infectious Diseases Fellowship Program