Brian DeBosch, M.D., Ph.D.

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Diabetes Research Center
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173


  • BS, Summa Cum Laude Distinction, University of Michigan2001
  • MD, Washington University School of Medicine2008
  • PhD, Olin Fellowship, Washington University School of Medicine2008


  • Residency, St. Louis Children's Hospital2008 - 2010
  • Fellowship - Accelerated Research Pathway, Washington University School of Medicine2010 - 2014

Licensure and Board Certification

  • Basic Life Support 2008
  • Neonatal Resuscitation Program 2008
  • Pediatric Advanced Life Support 2008
  • American Board of Pediatrics 2013
  • MO, Physician & Surgeon License 2015
  • Pediatric Gastroenterology, Hepatology & Nutrition 2015


  • National Merit Scholar1997
  • Regents-Alumni Scholar, University of Michigan, Ann Arbor1997
  • UPAAM Outstanding Youth of Michigan Scholar1997
  • Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor1997 - 2001
  • Ford Endowed Merit Scholar1997 - 2001
  • James B. Angell Scholar, University of Michigan, Ann Arbor1997 - 2001
  • Class Honors Award, University of Michigan, Ann Arbor1998 - 2001
  • Sophomore Honors Award, University of Michigan, Ann Arbor1999
  • Telluride Association Scholar1999 - 2001
  • Barry M. Goldwater Scholar2000 - 2001
  • Delta Phi Alpha National German Honor Society2001 - Pres
  • National Council on Undergraduate Research Award2001
  • Highest Honors Thesis Distinction, University of Michigan, Ann Arbor2001 - 2001
  • Summa Cum Laude, University of Michigan, Ann Arbor2001 - 2001
  • Triple Crown Award - St. Louis Children's Hospital2011
  • Digestive Diseases Research Center P&F Award2013 - 2015
  • Faculty Scholar - Children's Discovery Institute2014 - Pres
  • Nutrition & Obesity Research Center P&F Award2014 - Pres
  • Scholar - Child Health Research Center of Washington University School of Medicine2014 - Pres
  • Early Investigator Award - the Endocrine Society2015 - Pres
  • American Gastroenterological Association / Gilead Sciences Research Scholars Award in Liver Disease2015 - 2018
  • St. Louis Children's Hosptial Recognition Award2015
  • Robert Wood Johnson Foundation Scholar - Amos Medical Faculty Development Program2016 - Pres
  • United States Department of Defense Discovery Award2017 - Pres
  • Inductee, Society for Pediatric Research2018 - Pres
  • American Gastroenterological Association (AGA) / American Association for the study of Liver Diseases (AASLD) Conference Travel Award2018 - 2018
  • St. Louis Children's Hospital Triple Crown Award for Safe, Effective and Exceptional Patient Care2018 - 2018
  • Co-Inventor (Paul Hruz, MD, PhD), LEAP Inventor Challenge - Washington University School of Medicine Skandalaris Center: "Novel Treatment of Fatty Liver Disease"2018 - Pres
  • AGA/AASLD Young Investigator Conference Travel Award2018 - Pres
  • AGA-Allergan Pilot Research Award in Non-Alcoholic Fatty Liver Disease2019 - Pres

Selected Publications view all (28)

Publication Co-Authors

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426 
Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMID:24803506 
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214 
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932 
Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250 
Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162 
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450 
TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254 
Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328 
Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486 
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