Anthony R. French, M.D., Ph.D.  french_a@wustl.edu

Division Chief, Rheumatology
Associate Professor of Pediatrics, Pathology & Immunology, and Biomedical Engineering, Washington University School of Medicine
Researcher, Pathobiology
RheumatologyPathobiologyPediatrics

phone: (314) 454-6005

Research Interests

Anthony R. French received his M.D. and Ph.D. degrees from the University of Illinois at Urbana-Champaign. His graduate work was with Dr. Douglas Lauffenburger studying receptor-mediated endocytosis and intracellular sorting. He completed his residency in Pediatrics at the Mayo Clinic in Rochester, MN and his fellowship in Pediatric Rheumatology at Washington University School of Medicine in St. Louis, MO. His clinical interests include juvenile rheumatoid arthritis, juvenile dermatomyositis, vasculitis, and pediatric SLE. His research is focused on the role of natural killer (NK) cells in the early innate immune response and is motivated by the hypothesis that a clearer understanding of in vivo NK cell responses and homeostasis may lead to novel therapeutic interventions in autoimmune diseases.

Education

  • BS, University of Minnesota1989
  • MSc, University of Illinois1993
  • PhD, University of Illinois1995
  • MD, University of Illinois1997

Training

  • Residency, Mayo Graduate School of Medicine1997 - 2000
  • Fellow, Pediatric Rheumatology, Washington University School of Medicine2000 - 2003

Licensure and Board Certification

  • American Board of Pediatrics 2000
  • MO, Physician and Surgeon 2003
  • Pediatric Rheumatology 2004

Honors

  • Procter and Gamble Fellowship1990 - 1991
  • Chevron Fellowship1991 - 1992
  • Alpha Omega Alpha1996
  • Lange Medical Pub. Award for Outstanding Performance in Medical School1997
  • Ross Award for Excellence in Pediatrics1997
  • Yardy Award for Excellence in Family Medicine1997
  • Howard Hughes Medical Institute (HHMI) Faculty Development Award2002 - 2005
  • Scholar, Child Health Research Center of Excellence, Washington Univ2006 - 2008
  • Basil O'Connor Scholar Award, March of Dimes2007 - 2009
  • Elected to Society of Pediatric Research2010
  • Elected to American Society for Clinical Investigation2014

Selected Publications view all (49)


Publication Co-Authors

1.
Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe. 2015;17(1):85-97. doi:10.1016/j.chom.2014.11.004  PMCID:PMC4297260  PMID:25482432 
2.
Elevated double negative T cells in pediatric autoimmunity. J Clin Immunol. 2014;34(5):594-9. doi:10.1007/s10875-014-0038-z  PMCID:PMC4047151  PMID:24760111 
3.
Murine cytomegalovirus protein pM92 is a conserved regulator of viral late gene expression. J Virol. 2014;88(1):131-42. doi:10.1128/JVI.02684-13  PMCID:PMC3911726  PMID:24131717 
4.
MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191(12):5904-13. doi:10.4049/jimmunol.1301950  PMCID:PMC3863634  PMID:24227772 
5.
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. Lupus. 2013;22(13):1382-7. doi:10.1177/0961203313507990  PMCID:PMC3840537  PMID:24106215 
6.
Markers of nonselective and specific NK cell activation. J Immunol. 2013;190(12):6269-76. doi:10.4049/jimmunol.1202533  PMCID:PMC3679313  PMID:23656738 
7.
Natural killer cell functional defects in pediatric patients with severe and recurrent herpesvirus infections. J Infect Dis. 2013;207(3):458-68. doi:10.1093/infdis/jis701  PMCID:PMC3693586  PMID:23175766 
8.
Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling. Blood. 2013;121(2):286-97. doi:10.1182/blood-2012-05-429241  PMCID:PMC3544114  PMID:23175687 
9.
Mechanistic model of natural killer cell proliferative response to IL-15 receptor stimulation. PLoS Comput Biol. 2013;9(9):e1003222. doi:10.1371/journal.pcbi.1003222  PMCID:PMC3772054  PMID:24068905 
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