Pediatric Research

Research Interests

Dr. Rosen evaluates children on the Infectious Diseases service at St. Louis Children's Hospital. In the research lab, he studies basic pathogenic mechanisms of Klebsiella pneumoniae. This organism often carries sets of genes that render it resistant to most, if not all, antibiotics available. Klebsiella, and other carbapenem-resistant Enterobacteriaceae (CRE), have recently been assigned a threat level of urgent by the CDC. Utilizing mouse models of pneumonia and urinary tract infection, Dr. Rosen dissects mechanisms by which Klebsiella pneumoniae infects the host. Specific interests includes differential regulation of virulence determinants, including type 1 pili and capsule, and adaptive immune responses to Klebsiella in the lung. The ultimate goal is to develop further understanding of Klebsiella pneumoniae pathogenesis, which may reveal alternative therapies to combat these resistant organisms.

Education

• BS, Highest Distinction and Highest Honors, University of Michigan, 2002
• MD, Washington University School of Medicine, 2010
• PhD, Washington University School of Medicine, 2010

Training

• Pediatric Internship and Residency, St. Louis Children's Hospital, 2010 - 2012
• Pediatric Infectious Disease Fellowship, Washington University School of Medicine, St. Louis Children's Hospital, 2012 - 2016

Licensure and Board Certification

• MO, Physician and Surgeon License , 2012
• General Pediatrics, American Board of Pediatrics , 2013

Honors

• Farmington Rotary Foundation Daniel Waldman Memorial Scholarship, 1998
• State of Michigan House of Representatives Certificate of Recognition, 1998
• University of Michigan Regents-Alumni Scholarship, 1998
• William Beaumont Hospital Scholarship, 1998 - 2001
• University of Michigan James B. Angell Scholar, 1999 - 2002
• National Stark Scholarship for Chemistry and Biochemistry, 2001
• American Institute of Chemistry Merit Award for Biochemistry, 2002
• Washington University Medical School Teaching Assistant of the Year, 2007
• Washington University Teaching Citation, 2008
• Alexander Berg Prize for Microbiology Research, 2010
• St. Louis Children’s Hospital Chief Resident Award, 2012
• Pediatric Infectious Diseases Society Fellowship Award, 2013 - 2015
• Oliver Langenberg Physician-Scientist Training Program Post-Doctoral Trainee, Washington University School of Medicine, 2014 - 2017
• St. Louis Children’s Hospital Outstanding Fellow Teaching Award, 2015 - 2016
• Pediatric Infectious Diseases Society Fellow Video Award, 2015

Selected Publications view all (5)

All Publications view selected (5)

Publication Co-Authors

David A. Hunstad, M.D.

Ian T. Lackey, BS

S. Celeste Morley, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with David A. Rosen, M.D., Ph.D.