Zachary A. Vesoulis, MD MSCI  vesoulis_z@kids.wustl.edu

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Instructor in Pediatrics, Newborn Medicine
Researcher, Patient Oriented Research Unit
Newborn Medicine

phone: (314) 454-6148

Research Interests

I am interested in understanding the interaction between the brain and the cardiovascular system, in both preterm and term infants, and how disruption of this connection contributes to the most common forms of neonatal brain injury including intraventricular hemorrhage, white matter injury, hypoxic-ischemic injury, and seizures. In particular, the work in our research lab focuses on the relationship between systemic perfusion and autoregulatory control of cerebral blood flow. We utilize high-resolution multi-modality physiology measurements (ECG, arterial blood pressure, NIRS, pulse oximetry, EEG/aEEG) in conjunction with signal processing algorithms to build a model of this interaction and better understand the mechanisms of control.

The goal of this work is to understand the factors that contribute to the pathogenesis of brain injury in neonates, provide a more informed prognosis to families, and ultimately, to develop new neuroprotective strategies to prevent brain injury altogether.

Education

  • BA, Miami University2005
  • MD, The Ohio State University2009
  • MSCI, Washington University2019

Training

  • Internship, St. Louis Children's Hospital2009 - 2010
  • Residency, St. Louis Children's Hospital2010 - 2011
  • Fellowship, Washington University School of Medicine2011 - 2014

Licensure and Board Certification

  • 2009 - 2021Neonatal Resuscitation Program
  • 2009 - 2021Advanced Cardiac Life Support
  • 2009 - 2021Basic Life Support
  • 2009 - 2021Pediatric Advanced Life Support
  • 2013 - 2017Advanced Trauma Life Support
  • 2014 - PresMO, Medical License
  • 2014 - PresAmerican Board of Pediatrics, General Pediatrics
  • 2016 - PresAmerican Board of Pediatrics, Neonatal-Perinatal Medicine
  • 2018 - 2020IL, Medical License

Honors

  • Miami University Scholar-Leader Award2003
  • Alspaugh Award for Professionalism in the Field of Medicine2005 - 2009
  • James P. Keating Outstanding Resident Award2011
  • PAS Young Investigator's Travel Award2014
  • Outstanding Fellow Teaching Award2014
  • Travel Award, Burroughs Wellcome Fund2016
  • Outstanding Citizenship Award, Clinical Research Training Center2016
  • Early Career Investigator Highlight - Pediatric Research2017

Selected Publications view all (38)


Publication Co-Authors

1.
Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2018;103(4):F377-F382. PMCID:PMC6192544  PMID:28942435 
2.
Gestational age-dependent relationship between cerebral oxygen extraction and blood pressure. Pediatr Res. 2017;82(6):934-939. PMCID:PMC5685915  PMID:28902182 
3.
Low-frequency blood pressure oscillations and inotrope treatment failure in premature infants. J Appl Physiol (1985). 2017;123(1):55-61. PMCID:PMC6157481  PMID:28428252 
4.
Early hyperoxia burden detected by cerebral near-infrared spectroscopy is superior to pulse oximetry for prediction of severe retinopathy of prematurity. J Perinatol. 2016;36(11):966-971. PMCID:PMC5079836  PMID:27559717 
5.
Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555 
6.
A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. doi:10.1038/pr.2015.238  PMCID:PMC4821724  PMID:26571222 
7.
Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515 
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