Jeffrey J. Bednarski, M.D., Ph.D.

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Assistant Professor of Pediatrics, Hematology and Oncology
Hematology and Oncology

phone: (314) 454-6018

Research Interests

Dr. Bednarski's research centers on the development of the immune system. During lymphocyte differentiation, the rearrangement of the antigen receptor genes is essential to ensure a diverse and function immune response. This process requires the intentional generation of breaks in DNA at specific locations in the genes. These breaks are subsequently repaired with removal of some DNA and joining of the remaining segments. The DNA breaks pose an extreme risk to the developing cells. Mis-repair can lead to cell death or to translocations that can result in leukemias and lymphomas. Therefore, it is critical that the breaks be carefully managed by cellular processes that ensure proper repair and maintenance of genomic integrity. Dr. Bednarski's research focuses on how the signals from this DNA damage cooperate with other developmental processes to direct lymphocyte differentiation and survival. His overall goals are to understand the signals important for lymphocyte development and how these signals may be corrupted and thus contribute to the generation of leukemia and lymphoma.


  • BS, Summa Cum Laude, Duke University1995
  • PhD, University of Michigan2003
  • MD, Graduation with Distinction in Research, University of Michigan2003


  • Postdoctoral Fellow in Pediatric Hematology-Oncology, Boston Children's Hospital2003 - 2003
  • Resident in Pediatrics, St. Louis Children's Hospital2003 - 2006
  • Clinical Fellow in Pediatric Hematology-Oncology, Washington University School of Medicine2006 - 2009
  • Postdoctoral Fellow in Immunology, Washington University School of Medicine2007 - 2013

Licensure and Board Certification

  • 2006 - PresAmerican Board of Pediatrics, Board Certified
  • 2009 - PresMO, Medical License
  • 2011 - PresPediatric Hematology-Oncology, Board Certified

Honors and Awards

  • Phi Eta Sigma, National Freshman Honor Society1992
  • Golden Key National Honor Society1993
  • National Institute of General Medicine Summer Scholar1993
  • Phi Beta Kappa1994
  • Phi Lambda Upsilon, National Honorary Chemical Society1994
  • Summa cum laude graduate, Duke University1995
  • Regent's Fellowship, University of Michigan Rackham Graduate School1997 - 2001
  • Graduation with Distinction in Research, University of Michigan Medical School2003
  • James P. Keating Ouststanding Resident Award, St. Louis Children's Hospital2005
  • David Gilstrap Memorial Award, St. Louis Children's Hospital2008
  • Hyundai Hope on Wheels Scholar2012 - 2013
  • Hyundai Hope on Wheels Scholar2012 - 2013
  • American Society of Hematology Junior Faculty Scholar2018 - 2020
  • American Society of Hematology Junior Faculty Scholar Award2018 - Pres
  • Distinguished Service Teaching Award, Washington University School of Medicine2019
  • Distinguished Service Teaching Award, Washington University School of Medicine2019
  • Unsung Hero Award, Department of Pediatrics, Washington University School of Medicine2020
  • Department of Pediatrics Faculty Teaching Award2020
  • Department of Pediatrics Faculty Unsung Hero Award2020

Selected Publications view all (43)

Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma. Immunity. 2015;42(1):186-98. doi:10.1016/j.immuni.2014.12.021  PMCID:PMC4302272  PMID:25607463 
Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498 
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med. 2013;210(2):233-9. doi:10.1084/jem.20121605  PMCID:PMC3570110  PMID:23382544 
Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle. 2012;11(22):4129-34. doi:10.4161/cc.22021  PMCID:PMC3524208  PMID:23032308 
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med. 2012;209(1):11-7. doi:10.1084/jem.20112078  PMCID:PMC3260864  PMID:22201128 
Lymphocyte development: integration of DNA damage response signaling. Adv Immunol. 2012;116:175-204. doi:10.1016/B978-0-12-394300-2.00006-5  PMID:23063077 
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108(5):2022-7. doi:10.1073/pnas.1013295108  PMCID:PMC3033293  PMID:21245316 
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. 2011;469(7329):245-9. doi:10.1038/nature09585  PMCID:PMC3150591  PMID:21160476 
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009;206(3):669-79. doi:10.1084/jem.20081326  PMCID:PMC2699138  PMID:19221393 
A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. J Biol Chem. 2004;279(28):29615-21. doi:10.1074/jbc.M403507200  PMID:15123639 
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