Pediatric Research

Avraham Beigelman, M.D. beigelmana@wustl.edu

View my lab

Allergy, Immunology and Pulmonary Medicine Pediatric Research

phone: (314) 454-2694

Education

MD, Ben-Gurion University of the Negev, 2000
MSCI, Washington University School of Medicine, 2011

Training

Internship, Shaare Tzedek Medical Center, The Hebrew University, 1999 - 2000
Pediatric Residency, Soroka Medical Center, Ben-Gurion University of the Negev, 2001 - 2005
Clinical Fellow, Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Washington University School of Medicine, 2006 - 2009

Licensure and Board Certification

Medical License, Israel , 2001
Diplomate, Israel Board of Pediatrics , 2005
ECFMG Certified , 2005
MO, Medical License , 2009
KY, Medical License , 2009
Diplomate, Israel Board of Allergy & Immunology , 2011

Honors

Goldman's Fund Research Award for Resident. Faculty of Health Science, Ben-Gurion University, Beer-Sheva, Israel, 2002
Young Investigator Research Award. Israel Society of Clinical Pediatrics Annual Meeting, Tel Aviv, Israel, February 2005, 2005
House Officer Research Award. Pediatric Academic Societies (PAS) Annual Meeting, Washington DC, May, 2005
ACAAI Travel Grant, 2007
AAAAI Travel Grant, 2007 - 2009
Young Faculty Research Award. American College of Asthma, Allergy and Immunology (ACAAI)., 2009
KL2 Career Development Award (NIH KL2 TR000450): Attenuation of Airway Inflammation and Prevention of Recurrent Wheezing Following Respiratory Syncytial Virus (RSV) Bronchiolitis. Supports extended clinical outcomes for the above project, 2011
Research Award: Children’s Discovery Institute (CDI), Washington University School of Medicine, 2011
Research Award: Institute of Clinical & Translational Sciences (ICTS, #CTSA402), Washington University School of Medicine: Pilot Study: Azithromycin to Prevent Asthma Following RSV Bronchiolitis, 2011

Selected Publications view all (36)

Publication Co-Authors

Gregory A. Storch, M.D.

Marwan Shinawi, M.D.

Jeffrey J. Bednarski, M.D., Ph.D.

Kristine Wylie, Ph.D.

Richard Buller, Ph.D. D(ABMM)

Elizabeth C. Utterson, M.D.

Mario Castro

Katherine Rivera-Spoljaric, M.D., MSCI

Jane M. Garbutt, M.D.

Leonard B. Bacharier, M.D.

1.	Beigelman A, Bacharier LB. Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. Curr Opin Allergy Clin Immunol. 2016;16(2):172-8. doi:10.1097/ACI.0000000000000244 PMID:26854761
2.	Beigelman A, Bacharier LB. Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks. J Allergy Clin Immunol Pract. 2016;4(1):1-8. doi:10.1016/j.jaip.2015.10.003 PMCID:PMC4715860 PMID:26772922
3.	Beigelman A, Durrani S, Guilbert TW. Should a Preschool Child with Acute Episodic Wheeze be Treated with Oral Corticosteroids? A Pro/Con Debate. J Allergy Clin Immunol Pract. 2016;4(1):27-35. doi:10.1016/j.jaip.2015.10.017 PMID:26772924
4.	Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute’s AsthmaNet. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015;314(19):2034-44. doi:10.1001/jama.2015.13896 PMCID:PMC4757487 PMID:26575060
5.	Beigelman A, Bacharier LB, Baty J, Buller R, Mason S, Schechtman KB, Sajol G, Isaacson-Schmid M, Castro M, Storch GA. Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis? J Allergy Clin Immunol. 2015;136(4):1129-31. doi:10.1016/j.jaci.2015.06.011 PMCID:PMC4600448 PMID:26215052
6.	Beigelman A, Bacharier LB. Reply: To PMID 25458910. J Allergy Clin Immunol. 2015;136(4):1135-6. doi:10.1016/j.jaci.2015.07.013 PMID:26309182
7.	Beigelman A, Isaacson-Schmid M, Sajol G, Baty J, Rodriguez OM, Leege E, Lyons K, Schweiger TL, Zheng J, Schechtman KB, Castro M, Bacharier LB. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2015;135(5):1171-1178.e1. doi:10.1016/j.jaci.2014.10.001 PMCID:PMC4426225 PMID:25458910
8.	Beigelman A, Chipps BE, Bacharier LB. Update on the utility of corticosteroids in acute pediatric respiratory disorders. Allergy Asthma Proc. 2015;36(5):332-8. doi:10.2500/aap.2015.36.3865 PMCID:PMC4548893 PMID:26314814
9.	Collins AD, Beigelman A. An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children. Ther Adv Respir Dis. 2014;8(6):182-90. doi:10.1177/1753465814552283 PMCID:PMC4253569 PMID:25294845

1.	O’Connor GT, Lynch S, Jaffee , Calatroni A, Gergen P, Bacharier LB, Beigelman A, Bloomberg G, Johnson CC, Kattan M, Sandel M, Wood R, Faruqi A, Santee C, Fujimura KE, Fadrosh DF, Boushey H, Visness C, Gern JE for the NIH/NIAID Inner-City-Asthma Consortium. Early-life home environment and the risk of developing asthma among inner-city children. J Allergy Clin Immunol. 2017. doi:In Press
2.	Beigelman A, Bacharier LB. Management of preschool recurrent wheezing and asthma: a phenotype-based approach. Curr Opin Allergy Clin Immunol. 2017;17(2):131-138. PMID:28118241
3.	Beigelman A. To Eat or Not to Eat? Introduction of Food After Negative Oral Food Challenge. J Allergy Clin Immunol Pract. 2017;5(2):477-478. PMID:28283161
4.	Zafar R, Ver Heul A, Beigelman A, Bednarski JJ, Bayliss SJ, Dehner LP, Rosman IS, Coughlin CC. Omenn Syndrome Presenting with Striking Erythroderma and Extreme Lymphocytosis in a Newborn. Pediatr Dermatol. 2017;34(1):e37-e39. PMID:27862277
5.	Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ, National Institutes of Health/National Heart, Lung, and Blood Institute AsthmaNet. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016;138(6):1608-1618.e12. PMCID:PMC5148729 PMID:27777180
6.	Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ, National Heart, Lung and Blood Institute's “AsthmaNet”. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2016. PMID:27838347
7.	Zhou Y, Bacharier LB, Isaacson-Schmid M, Baty J, Schechtman KB, Sajol G, Wylie K, Storch GA, Castro M, Beigelman A. Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze. J Allergy Clin Immunol. 2016;138(4):1215-1219.e5. PMCID:PMC5056860 PMID:27339392
8.	Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W, NIH/NHLBI AsthmaNet. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016;375(7):619-30. PMCID:PMC5085065 PMID:27532828
9.	Beigelman A, Bacharier LB. Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. Curr Opin Allergy Clin Immunol. 2016;16(2):172-8. doi:10.1097/ACI.0000000000000244 PMID:26854761
10.	Beigelman A, Bacharier LB. Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks. J Allergy Clin Immunol Pract. 2016;4(1):1-8. doi:10.1016/j.jaip.2015.10.003 PMCID:PMC4715860 PMID:26772922
11.	Beigelman A, Durrani S, Guilbert TW. Should a Preschool Child with Acute Episodic Wheeze be Treated with Oral Corticosteroids? A Pro/Con Debate. J Allergy Clin Immunol Pract. 2016;4(1):27-35. doi:10.1016/j.jaip.2015.10.017 PMID:26772924
12.	Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute’s AsthmaNet. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015;314(19):2034-44. doi:10.1001/jama.2015.13896 PMCID:PMC4757487 PMID:26575060
13.	Beigelman A, Bacharier LB, Baty J, Buller R, Mason S, Schechtman KB, Sajol G, Isaacson-Schmid M, Castro M, Storch GA. Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis? J Allergy Clin Immunol. 2015;136(4):1129-31. doi:10.1016/j.jaci.2015.06.011 PMCID:PMC4600448 PMID:26215052
14.	Beigelman A, Bacharier LB. Reply: To PMID 25458910. J Allergy Clin Immunol. 2015;136(4):1135-6. doi:10.1016/j.jaci.2015.07.013 PMID:26309182
15.	Beigelman A, Castro M, Schweiger TL, Wilson BS, Zheng J, Yin-DeClue H, Sajol G, Giri T, Sierra OL, Isaacson-Schmid M, Sumino K, Schechtman KB, Bacharier LB. Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants. J Pediatric Infect Dis Soc. 2015;4(3):182-8. PMCID:PMC4554201 PMID:26336601
16.	Beigelman A, Isaacson-Schmid M, Sajol G, Baty J, Rodriguez OM, Leege E, Lyons K, Schweiger TL, Zheng J, Schechtman KB, Castro M, Bacharier LB. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2015;135(5):1171-1178.e1. doi:10.1016/j.jaci.2014.10.001 PMCID:PMC4426225 PMID:25458910
17.	Beigelman A, Chipps BE, Bacharier LB. Update on the utility of corticosteroids in acute pediatric respiratory disorders. Allergy Asthma Proc. 2015;36(5):332-8. doi:10.2500/aap.2015.36.3865 PMCID:PMC4548893 PMID:26314814
18.	Collins AD, Beigelman A. An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children. Ther Adv Respir Dis. 2014;8(6):182-90. doi:10.1177/1753465814552283 PMCID:PMC4253569 PMID:25294845
19.	Beigelman A, Zeiger RS, Mauger D, Strunk RC, Jackson DJ, Martinez FD, Morgan WJ, Covar R, Szefler SJ, Taussig LM, Bacharier LB, Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing. J Allergy Clin Immunol. 2014;133(5):1489-92, 1492.e1-3. doi:10.1016/j.jaci.2014.02.024 PMCID:PMC4086617 PMID:24698320
20.	Beigelman A, Zeiger RS, Kelly HW, Bacharier LB, Childhood Asthma Research and Education Network of National Heart, Lung, and Blood Institute. The challenge of treating preschool wheezing episodes: the need for evidence-based approaches. J Allergy Clin Immunol. 2014;133(4):1016-7. doi:10.1016/j.jaci.2014.01.005 PMID:24529412
21.	Beigelman A, Weinstock GM, Bacharier LB. The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma. Curr Opin Allergy Clin Immunol. 2014;14(2):137-42. doi:10.1097/ACI.0000000000000036 PMID:24451910
22.	Beigelman A, Bacharier LB. Infection-induced wheezing in young children. J Allergy Clin Immunol. 2014;133(2):603-4. doi:10.1016/j.jaci.2013.12.001 PMCID:PMC4086475 PMID:24636478
23.	Miller NB, Beigelman A, Utterson E, Shinawi M. Transient massive trimethylaminuria associated with food protein-induced enterocolitis syndrome. JIMD Rep. 2014;12:11-5. doi:10.1007/8904_2013_238 PMCID:PMC3897788 PMID:23821320
24.	Beigelman A, Bacharier LB. The role of early life viral bronchiolitis in the inception of asthma. Curr Opin Allergy Clin Immunol. 2013;13(2):211-6. doi:10.1097/ACI.0b013e32835eb6ef PMID:23385289
25.	Beigelman A, King TS, Mauger D, Zeiger RS, Strunk RC, Kelly HW, Martinez FD, Lemanske RF Jr, Rivera-Spoljaric K, Jackson DJ, Guilbert T, Covar R, Bacharier LB, Childhood Asthma Research and Education Network of National Heart, Lung, and Blood Institute. Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? J Allergy Clin Immunol. 2013. doi:10.1016/j.jaci.2013.01.034 PMID:23498594
26.	Beigelman A, Strunk RC, Garbutt JM, Schechtman KB, Jaenicke MW, Stein JS, Bacharier LB. Clinical and laboratory factors associated with negative oral food challenges. Allergy Asthma Proc. 2012;33(6):467-73. doi:10.2500/aap.2012.33.3607 PMCID:PMC3522388 PMID:23394503
27.	Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF Jr, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM, CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011;365(21):1990-2001. doi:10.1056/NEJMoa1104647 PMCID:PMC3247621 PMID:22111718
28.	Beigelman A, Mikols CL, Gunsten SP, Cannon CL, Brody SL, Walter MJ. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis. Respir Res. 2010;11:90. doi:10.1186/1465-9921-11-90 PMCID:PMC2906448 PMID:20591166
29.	Beigelman A, Gunsten S, Mikols CL, Vidavsky I, Cannon CL, Brody SL, Walter MJ. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest. 2009;136(2):498-506. doi:10.1378/chest.08-3056 PMID:19429717
30.	Beigelman A, Mauger DT, Phillips BR, Zeiger RS, Taussig LM, Strunk RC, Bacharier LB, Childhood Asthma Research and Education (CARE) Network, National Heart, Lung and Blood Institute. Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing. Ann Allergy Asthma Immunol. 2009;103(2):108-13. doi:10.1016/S1081-1206(10)60162-7 PMID:19739422
31.	Beigelman A, Levy J, Hadad N, Pinsk V, Haim A, Fruchtman Y, Levy R. Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. Clin Immunol. 2009;130(3):365-72. doi:10.1016/j.clim.2008.09.005 PMID:18955016
32.	Haim A, Grunwald MH, Kapelushnik J, Moser AM, Beigelman A, Reuveni H. Hypereosinophilia in red scaly infants with scabies. J Pediatr. 2005;146(5):712. doi:10.1016/j.jpeds.2004.08.023 PMID:15870685
33.	Beigelman A, Marks KA, Landau D. Congenital isolated pleural effusion associated with obstructive uropathy. Isr Med Assoc J. 2005;7(4):271-2. PMID:15847214
34.	Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, Oron A, Itskovich S, Ballin A, Houri S, Beigelman A, Lider O, Rechavi G, Amariglio N. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004;189(11):2057-63. doi:10.1086/420830 PMID:15143473
35.	Beigelman A, Leibovitz E, Sofer S. Septic shock associated with Shigella flexneri dysentery. Scand J Infect Dis. 2002;34(9):692-3. PMID:12374365
36.	Beigelman A, Wiznitzer A, Shoham-Vardi I, Vardi H, Holtcberg G, Mazor M. [Premature delivery in diabetes: etiology and risk factors]. Harefuah. 2000;138(11):919-23, 1008, 1007. PMID:10979399