Mary C. Dinauer, M.D., Ph.D.  dinauer_m@kids.wustl.edu

Fred M. Saigh Distinguished Chair in Pediatric Research, Washington University School of Medicine
Professor, Pathology & Immunology
Scientific Director, Children's Discovery Institute, Washington University School of Medicine
Pathology & ImmunologyDevelopmental BiologyHematology and OncologyPediatrics

phone: (314) 454-6018

Research Interests

Research interests: Dr. Dinauer studies the superoxide-generating leukocyte NADPH oxidase. Inactivating mutations in this enzyme result in chronic granulomatous disease (CGD), a primary immunodeficiency associated with recurrent bacterial and fungal infections as well as a variety of chronic inflammatory disorders, including inflammatory bowel disease and discoid lupus. These symptoms reflect the dual importance of the NADPH oxidase both for microbial killing and for negatively regulating cellular processes that limit inflammation by redox mechanisms. Moreover, hypomorphic NADPH oxidase gene variants are now linked to inflammatory bowel disease and autoimmunity.

Research interests are focused on the role of leukocyte oxidant production in the response to microbial pathogens, sterile inflammation, and predisposition to autoimmunity. Experimental approaches involve a combination of molecular and cell biology assays on human and mouse cells and use of mouse models, including recently developed mice lacking the NADPH oxidase in specific blood cell lineages. Current areas of study are a) host response to Aspergillus fumigatus, an opportunistic pathogen that is a major pathogen in CGD, likely reflecting both impaired fungicidal activity and excessive inflammation b) NADPH oxidase regulation of sterile inflammation and removal of apoptotic cells and c) synergy of NADPH oxidase deficiency with other lupus pre-disposing genes.

Education

  • BA, Lawrence University1975
  • PhD, University of Chicago1979
  • MD, University of Chicago1981

Training

  • Internship and Residency in Pediatrics, University of California1981 - 1984
  • Chief Residency in Pediatrics, University of California1984 - 1985
  • Fellowship in Pediatric Hematology/Oncology, Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School1985 - 1988

Licensure and Board Certification

  • National Board of Medical Examiners 1982
  • CA, California License 1983
  • MA, Massachusetts License 1986
  • American Board of Pediatrics 1986
  • IN, Indiana License 1991
  • MO, Missouri License 2012

Honors

  • Phi Beta Kappa1974
  • Summa Cum Laude, Lawrence University1975
  • Medical Scientist Training Program1975 - 1981
  • Alpha Omega Alpha1981
  • American Medical Women's Association Award, University of Chicago1981
  • Mary Roberts Scott Memorial Prize, University of Chicago1981
  • Medical Doctorate, with Honors, University of Chicago1981
  • Basil O'Connor Starter Scholar Research Award, March of Dimes1990 - 1992
  • JV Satterfield Arthritis Investigator, Arthritis Foundation1990 - 1993
  • American Society of Clinical Investigation1995
  • Excellence in Pediatrics Research Award, American Academy of Pediatrics1995
  • Soroptimist International of Indianapolis, Woman of Distinction Honoree1996
  • Lucia R. Briggs Distinguished Achievement Award, Lawrence University2000
  • Association of American Physicians2008
  • Fellow, American Association for the Advancement of Science2014

Selected Publications view all (169)


Publication Co-Authors

1.
PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. J Leukoc Biol. 2017;101(2):449-457. PMID:27543673 
2.
Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host Microbe. 2016;19(1):102-13. PMCID:PMC4714358  PMID:26764600 
3.
NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis. Blood. 2015;17(126(25)):2724-33. doi:10.1182/blood-2015-05-644773  PMID:26443623 
4.
Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. Am J Respir Cell Mol Biol. 2015;52(3):349-64. doi:10.1165/rcmb.2013-0316OC  PMCID:PMC4370257  PMID:25100610 
5.
Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox. J Clin Cell Immunol. 2014;5(3). PMCID:PMC4414043  PMID:25937994 
6.
Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic. ACS Chem Biol. 2014;9(2):551-61. doi:10.1021/cb400658k  PMCID:PMC3934373  PMID:24283977 
7.
Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498 
8.
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J. 2013;32(24):3130-44. doi:10.1038/emboj.2013.233  PMCID:PMC3981139  PMID:24185898 
9.
Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic. 2013;14(11):1118-1131. doi:10.1111/tra.12115  PMID:23980663 
10.
From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013;24(2):86-98. doi:10.1089/humc.2013.019  PMID:23845071 
11.
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 2013;121(17):3473-83. doi:10.1182/blood-2012-10-461913  PMCID:PMC3637016  PMID:23426944 
12.
Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice. Blood. 2012;120(16):3385-7. doi:10.1182/blood-2012-07-445619  PMID:23086626 
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