Paul W. Hruz, M.D., Ph.D.  Hruz_P@kids.wustl.edu

Division Chief, Endocrinology and Diabetes
Associate Professor of Pediatrics, Endocrinology and Diabetes
Associate Professor of Pediatrics, Cell Biology & Physiology
Cell Biology & PhysiologyDevelopmental BiologyEndocrinology and Diabetes

phone: (314) 454-6051

Research Interests

Dr. Hruz's research interests include intermediary carbohydrate metabolism, glucose transporter structure and function and mechanism of insulin action. Currently, the mechanism(s) by which HIV protease inhibitors cause serious adverse metabolic effects including peripheral lipoatrophy, visceral adiposity, hypertriglyceridemia, and insulin resistance are being investigated. The laboratory has discovered that HIV protease inhibitors selectively and reversibly inhibit the GLUT4 facilitative glucose transporter. Ongoing studies are being directed toward elucidating the selectivity of these drugs in blocking the activity of each of the known facilitative glucose transport proteins. The tertiary structure of the facilitative glucose transporters is also being investigated using state-of-the-art biophysical approaches.

Education

  • BS, Marquette University1987
  • PhD, Medical College of Wisconsin1993
  • MD, Medical College of Wisconsin1994

Training

  • Pediatric Residency, University of Washington1994 - 1997
  • Pediatric Endocrinology Fellowship, Washington University1997 - 2000

Licensure and Board Certification

  • Board Certified in General Pediatrics 1997
  • MO, Stae License 2000
  • Board Certified in Pediatric Endocrinology & Metabolism 2001

Honors

  • National Institute of Chemists Research and Recognition Award1987
  • Phi Beta Kappa1987
  • Phi Lambda Upsilon (Honorary Chemical Society)1987
  • American Heart Association Predoctoral Fellowship Award1988
  • Alpha Omega Alpha1994
  • Armond J. Quick Award for Excellence in Biochemistry1994
  • NIDDK/Diabetes Branch Most Outstanding Resident1994
  • Pfizer Postdoctoral Fellowship Award1998
  • Scholar, Child Health Research Center of Excellence in Developmental Biology at Washington University2002
  • Julio V Santiago, M.D. Scholar in Pediatrics2013

Selected Publications view all (48)


Publication Co-Authors

1.
Mammalian Glucose Transporter Activity is Dependent upon Anionic and Conical Phospholipids. J Biol Chem. 2016. doi:10.1074/jbc.M116.730168  PMID:27302065 
2.
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. doi:10.1126/scisignal.aac5472  PMID:26905426 
3.
The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir. Antimicrob Agents Chemother. 2015;59(10):6203-9. doi:10.1128/AAC.00899-15  PMCID:PMC4576095  PMID:26248369 
4.
Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4. Protein Sci. 2015. doi:10.1002/pro.2812  PMID:26402434 
5.
In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy. J Biol Chem. 2015;290(23):14441-53. doi:10.1074/jbc.M114.628826  PMID:25847249 
6.
Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding. J Biol Chem. 2014;289(23):16100-16113. doi:10.1074/jbc.M113.528430  PMCID:PMC4047383  PMID:24706759 
7.
Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy. Cardiovasc Endocrinol. 2012;1(4):74-82. doi:10.1097/XCE.0b013e32835bfb24  PMCID:PMC3686315  PMID:23795310 
8.
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol. 2012;11:63. doi:10.1186/1475-2840-11-63  PMCID:PMC3416696  PMID:22681646 
9.
Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes. 2011;60(10):2515-22. doi:10.2337/db11-0538  PMCID:PMC3178299  PMID:21813803 
10.
Molecular mechanisms for insulin resistance in treated HIV-infection. Best Pract Res Clin Endocrinol Metab. 2011;25(3):459-68. doi:10.1016/j.beem.2010.10.017  PMCID:PMC3115529  PMID:21663839 
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