David A. Hunstad, M.D.  dhunstad@wustl.edu

Division Chief, Infectious Diseases
Associate Professor of Pediatrics, Infectious Diseases
Associate Professor, Molecular Microbiology
Researcher, Pathobiology
Infectious DiseasesPathobiologyMolecular Microbiology

phone: 314 286-2710

Research Interests


Dr. Hunstad evaluates children on the Infectious Diseases service at St. Louis Children's Hospital. With his research team in the McDonnell Pediatric Research Building and Northwest Tower, he studies the interactions of Gram-negative bacteria with their hosts. He is particularly interested in mechanisms by which Gram-negative pathogens modulate host immune responses in order to establish infection. Related projects in the laboratory explore how chaperone proteins help bacteria to assemble virulence factors on their surfaces, and how bacterial adhesins can be leveraged to deliver antimicrobials to bacteria residing in host epithelia. His goal is to develop new targets for prevention and treatment of Gram-negative bacterial infections of the urinary tract, gastrointestinal tract, and central nervous system. He is the Director of the Pediatric ID Division and co-founded the Wash U Pediatric Physician-Scientist Training Program with his colleague Tony French, MD, PhD.

Education

  • B.A., summa cum laude, Carleton College1991
  • M.D., Washington University School of Medicine1995

Training

  • Intern and Resident in Pediatrics, St. Louis Children's Hospital1995 - 1998
  • Chief Resident in Pediatrics, St. Louis Children's Hospital1998 - 1999
  • Fellow, Pediatric Infectious Diseases, Washington University2000 - 2003

Licensure and Board Certification

  • MO, Physician and Surgeon1998
  • American Board of Pediatrics1999
  • ABP Sub-board of Pediatric Infectious Diseases2003
  • Neonatal Resuscitation Program2008

Honors

  • Dean's List, Carleton College1987 - 1991
  • CRC Press Award, Carleton College1988
  • Phi Beta Kappa Sophomore Award, Carleton College1989
  • Barry M. Goldwater Foundation Scholarship1990 - 1991
  • USA Today All-USA Academic Team1990 - 1991
  • Virgil Loeb, MD, Distinguished Alumni Scholarship, Washington University1991 - 1995
  • Finalist, American College of Physicians Award for Excellence in Physical Diagnosis1994
  • Fellow, Pediatric Scientist Development Program2001 - 2004
  • NIH Pediatric Research Loan Repayment Program Award2002 - 2006
  • Scholar, WU Child Health Research Center of Excellence2005 - 2008
  • Wall of Honor, SOAR Program, Red Wing, MN2006
  • Basil O'Connor Scholar Award, March of Dimes Foundation2009
  • Residents' Lecture Award (x2), St. Louis Children's Hospital2010
  • David Hunstad, MD, Distinguished Alumni Scholarship named by Washington University School of Medicine2015
  • Fellow, Pediatric Infectious Diseases Society2015
  • Best Doctors, St. Louis Magazine2015 - 2016

Selected Publications view all (10)


  1. Loughman JA, Yarbrough ML, Tiemann KM, Hunstad DA. Local generation of kynurenines mediates inhibition of neutrophil chemotaxis by uropathogenic Escherichia coli. Infect Immun. 2016;84(4):1176-83. PMCID:PMC4807489  PMID:26857571  
  2. Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016;213(4):649-58. doi:10.1093/infdis/jiv440  PMCID:PMC4721909  PMID:26347570  
  3. Hannan TJ, Hunstad DA. A murine model for Escherichia coli urinary tract infection. Methods Mol Biol. 2016;1333:159-75. doi:10.1007/978-1-4939-2854-5_14  PMCID:PMC4624421  PMID:26468108  
  4. Olson PD, Hruska KA, Hunstad DA. Androgens enhance male urinary tract infection severity in a new model. J Am Soc Nephrol. 2016;27(6):1625-34. PMCID:PMC4884108  PMID:26449605  
  5. Wagers PO, Tiemann KM, Shelton KL, Kofron WG, Panzner MJ, Wooley KL, Youngs WJ, Hunstad DA. Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model. Antimicrob Agents Chemother. 2015;59(9):5494-5502. doi:10.1128/AAC.00881-15  PMCID:PMC4538537  PMID:26124168  
  6. Wang JW, Hogan PG, Hunstad DA, Fritz SA. Vitamin D sufficiency and Staphylococcus aureus infection in children. Pediatr Infect Dis J. 2015;34(5):544-5. doi:10.1097/INF.0000000000000667  PMCID:PMC4400212  PMID:25860535  
  7. Danka ES, Hunstad DA. Cathelicidin augments epithelial receptivity and pathogenesis in experimental Escherichia coli cystitis. J Infect Dis. 2015;211(7):1164-73. doi:10.1093/infdis/jiu577  PMCID:PMC4366604  PMID:25336727  
  8. Lim YH, Tiemann KM, Heo GS, Wagers PO, Rezenom YH, Zhang S, Zhang F, Youngs WJ, Hunstad DA, Wooley KL. Preparation and in vitro antimicrobial activity of silver-bearing degradable polymeric nanoparticles of polyphosphoester-block-poly(L-lactide). ACS Nano. 2015;9(2):1995-2008. doi:10.1021/nn507046h  PMCID:PMC4455953  PMID:25621868  
  9. Lau ME, Danka ES, Tiemann KM, Hunstad DA. Bacterial lysis liberates the neutrophil migration suppressor YbcL from the periplasm of uropathogenic Escherichia coli. Infect Immun. 2014;82(12):4921-30. PMCID:PMC4249291  PMID:25183735  
  10. Al-Zubeidi D, Burnham CA, Hogan PG, Collins R, Hunstad DA, Fritz SA. Molecular epidemiology of recurrent cutaneous methicillin-resistant Staphylococcus aureus infections in children. J Pediatric Infect Dis Soc. 2014;3(3):261-264. doi:10.1093/jpids/pit046  PMCID:PMC4381745  PMID:25844165