Audrey R. Odom John, M.D., Ph.D.  aodom@wustl.edu

Assistant Professor of Pediatrics, Infectious Diseases
Infectious DiseasesPathobiologyMolecular Microbiology

phone: (314) 454-6050

Research Interests

There is an urgent need for new drugs to treat malaria, which causes nearly one million deaths per year, mostly in very young children. Our lab aims to improve the fundamental understanding of the basic molecular and cellular biology of the malaria parasite, Plasmodium falciparum, in order to identify new antimalarial drug targets. Our primary research goals are to understand the biological functions of specific metabolic and signaling pathways in the malaria parasite--that is, to understand what the parasite needs to make, and why it needs to make it.

Education

  • BS, summa cum laude, Duke University1996
  • PhD, Duke University School of Medicine2002
  • MD, Duke University School of Medicine2003

Training

  • Doctoral research: Duke University Medical Center, Advisor: John York PhD. Nuclear functions of an inositol polyphosphate kinase pathway1998 - 2002
  • Pediatric Residency (Special Alternative Pathway), University of Washington2003 - 2005
  • Fellowship research: University of Washington, Advisor: Wesley Van Voorhis MD PhD. Isoprenoid biosynthesis in the malaria parasite, Plasmodium falciparum2005 - 2008
  • Pediatric Infectious Diseases Fellowship, University of Washington2005 - 2008

Licensure and Board Certification

  • MO, Physician and Surgeon 2008
  • ABP, General Pediatrics, # 095581 2009
  • ABP Sub-board of Pediatric Infectious Diseases, # 1270 2011

Honors

  • Howard Hughes Medical Institute, Forum Fellows Grant1995
  • Phi Beta Kappa1996
  • Alpha Omega Alpha1998
  • American Cancer Society Institutional Research Grant Student Award1999
  • Harold M. Weintraub Graduate Student Award2001
  • Pediatric Infectious Diseases Society Fellowship Award2007
  • Scholar, WU Child Health Research Center of Excellence2008
  • Children's Discovery Institute, New Faculty Recruitment Award2009
  • Doris Duke Charitable Foundation Clinical Scientist Development Award2010
  • Mentor of the year, Washington University2010
  • Co-chair, Drug Discovery for Eukaryotic Pathogens and Parasites session, Keystone Symposium, Drug Discovery for Protozoan Parasites, Santa Fe, NM2012
  • Innovator award, St. Louis Academy of Sciences2012
  • Basil O'Connor Starter Scholar Award, March of Dimes2013
  • Election, Society for Pediatric Research2014
  • Grand Challenge winner and invited speaker, TEDxKC2015
  • Contributing member, Faculty of 10002015 - Pres
  • Burroughs Wellcome Fund, Investigator in the Pathogenesis of Infectious Diseases (PATH)2016
  • Emerging Leader Award, Duke University School of Medicine alumni association2016
  • American Chemical Society Infectious Diseases, Young Investigator Award2016

Selected Publications view all (32)


Publication Co-Authors

1.
Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr). Antimicrob Agents Chemother. 2015. doi:10.1128/AAC.00602-15  PMID:26124156 
2.
Malaria parasites produce volatile mosquito attractants. MBio. 2015;6(2). doi:10.1128/mBio.00235-15  PMCID:PMC4453533  PMID:25805727 
3.
Isoprenoid metabolism in apicomplexan parasites. Curr Clin Microbiol Rep. 2014;1(3-4):37-50. doi:10.1007/s40588-014-0006-7  PMCID:PMC4399553  PMID:25893156 
4.
Isoprenoid biosynthesis in Plasmodium falciparum. Eukaryot Cell. 2014;13(11):1348-59. doi:10.1128/EC.00160-14  PMCID:PMC4248697  PMID:25217461 
5.
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014;5:4467. doi:10.1038/ncomms5467  PMCID:PMC4112465  PMID:25058848 
6.
Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. Eukaryot Cell. 2013;12(2):215-23. doi:10.1128/EC.00073-12  PMID:23223036 
7.
Structural studies and protein engineering of inositol phosphate multikinase. J Biol Chem. 2012;287(42):35360-9. doi:10.1074/jbc.M112.365031  PMCID:PMC3471723  PMID:22896696 
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