Audrey R. Odom John, M.D., Ph.D.

Profile picture
Assistant Professor of Pediatrics, Infectious Diseases
School of MedicineInfectious Diseases

phone: (314) 454-6050

Research Interests

There is an urgent need for new drugs to treat malaria, which causes nearly one million deaths per year, mostly in very young children. Our lab aims to improve the fundamental understanding of the basic molecular and cellular biology of the malaria parasite, Plasmodium falciparum, in order to identify new antimalarial drug targets. Our primary research goals are to understand the biological functions of specific metabolic and signaling pathways in the malaria parasite--that is, to understand what the parasite needs to make, and why it needs to make it.


  • BS, summa cum laude, Duke University1996
  • MD, Medical Scientist Training Program (MD-PhD), AOA, Duke University School of Medicine2003
  • PhD, Duke University School of Medicine2002


  • Pediatric Residency (Special Alternative Pathway), University of Washington2003 - 2005
  • Pediatric Infectious Diseases Fellowship, University of Washington2005 - 2008

Licensure and Board Certification

  • MO, Physician and Surgeon, 2008 - Pres
  • ABP, General Pediatrics, # 095581, 2009 - Pres
  • ABP Sub-board of Pediatric Infectious Diseases, # 1270, 2011 - Pres


  • Howard Hughes Medical Institute, Forum Fellows Grant1995
  • Phi Beta Kappa1996
  • Alpha Omega Alpha1998
  • American Cancer Society Institutional Research Grant Student Award1999
  • Harold M. Weintraub Graduate Student Award2001
  • Pediatric Infectious Diseases Society Fellowship Award2007
  • Scholar, WU Child Health Research Center of Excellence2008
  • Children's Discovery Institute, New Faculty Recruitment Award2009
  • Doris Duke Charitable Foundation Clinical Scientist Development Award2010
  • Mentor of the year, Washington University2010
  • Co-chair, Drug Discovery for Eukaryotic Pathogens and Parasites session, Keystone Symposium, Drug Discovery for Protozoan Parasites, Santa Fe, NM2012
  • Innovator award, St. Louis Academy of Sciences2012
  • Basil O'Connor Starter Scholar Award, March of Dimes2013
  • Election, Society for Pediatric Research2014
  • Grand Challenge winner and invited speaker, TEDxKC2015
  • Contributing member, Faculty of 10002015 - Pres
  • Burroughs Wellcome Fund, Investigator in the Pathogenesis of Infectious Diseases (PATH)2016
  • Emerging Leader Award, Duke University School of Medicine alumni association2016
  • American Chemical Society Infectious Diseases, Young Investigator Award2016

Selected Publications view all (37)

Publication Co-Authors

Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr). Antimicrob Agents Chemother. 2015. doi:10.1128/AAC.00602-15  PMID:26124156 
Malaria parasites produce volatile mosquito attractants. MBio. 2015;6(2). doi:10.1128/mBio.00235-15  PMCID:PMC4453533  PMID:25805727 
Isoprenoid metabolism in apicomplexan parasites. Curr Clin Microbiol Rep. 2014;1(3-4):37-50. doi:10.1007/s40588-014-0006-7  PMCID:PMC4399553  PMID:25893156 
Isoprenoid biosynthesis in Plasmodium falciparum. Eukaryot Cell. 2014;13(11):1348-59. doi:10.1128/EC.00160-14  PMCID:PMC4248697  PMID:25217461 
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014;5:4467. doi:10.1038/ncomms5467  PMCID:PMC4112465  PMID:25058848 
Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. Eukaryot Cell. 2013;12(2):215-23. doi:10.1128/EC.00073-12  PMID:23223036 
Structural studies and protein engineering of inositol phosphate multikinase. J Biol Chem. 2012;287(42):35360-9. doi:10.1074/jbc.M112.365031  PMCID:PMC3471723  PMID:22896696 
© 2019 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130