David A. Rudnick, M.D., Ph.D.  rudnick_d@wustl.edu

Researcher, Developmental Biology
Developmental BiologyGastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Research Interests

The over-arching goal of my research program has been to elucidate the mechanisms that regulate liver regeneration so as to improve the management of patients with liver diseases. In pursuit of this goal, my laboratory has accumulated extensive experience and expertise with the rodent partial hepatectomy paradigm and other experimental models of liver regeneration, and we have contributed broadly to current understanding of the mechanisms that regulate liver regeneration. Our previously published and preliminary data provide strong support for our central hypothesis that liver injuries induce changes in metabolism that initiate hepatic regeneration and, thus, that pro-regenerative therapeutic approaches targeting such metabolic alterations can be discovered. We recently reported data implicating protein acetylation as an important molecular link between the metabolic response to hepatic insufficiency and the initiation of liver regeneration, and we are also pursuing studies to examine interactions between metabolism and other mechanisms of epigenetic regulation during liver regeneration. These studies will serve as a vehicle towards new opportunities with which to improve the management of patients with acute and chronic liver disease. In a complementary area of investigation, we have sought to identify novel metabolic biomarkers of liver regeneration, and examine the utility of such markers in the management of pediatric acute liver failure (ALF) and other serious human liver disease. Such studies have informed our hypothesis that incorporation of metabolic bio-markers of liver regeneration into ALF outcomes-prediction algorithms will improve medical management of these patients, and, thus, should lead to novel opportunities with which to improve the management of human liver diseases. We recently initiated a new line of investigation, to elucidate the mechanisms that link dietary aflatoxin exposure to stunting, using a novel rat model which we developed. We are pursuing the hypothesis that toxin-induced injuries to the liver and the gut mediate such stunting.

Education

  • BS, University of Illinois1987
  • MD, Washington University School of Medicine1994
  • PhD, Washington University School of Medicine 1994

Training

  • Internship, St. Louis Children's Hospital1994 - 1995
  • Residency, St. Louis Children's Hospital1995 - 1997
  • Fellowship, Washington University School of Medicine1997 - 2000

Licensure and Board Certification

  • MO, 1997
  • American Board of Pediatrics, General Pediatrics 1997
  • American Board of Pediatrics, Sub-board of Pediatric Gastroenterology 2001
  • American Board of Pediatrics, General Pediatrics, Recertification 2004
  • American Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification 2008

Honors

  • Phi Beta Kappa, University of Illinois Chapter1987
  • Summa Cum Laude, University of Illinois1987
  • American Federation for Clinical Research, Medical Student Award, Washington University Medical School1992
  • Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral, Fellowship, Washington University Medical School1992
  • American College of Physicians Award for Excellence in Physical Diagnosis, Washington University Medical School1993
  • Alpha Omega Alpha, Washington University Medical School Chapter1994
  • The Dr. Phillip Needleman Pharmacology Award, Washington University Medical School1994
  • The George F. Gill Prize in Pediatrics, Washington University Medical School1994
  • Scholar of the Child Health Research Center for Excellence in Developmental Biology at Washington University Medical School2000 - 2003
  • NASPGHAN Young Faculty Investigator Award2003
  • Research Excellence in GI and Liver (REGAL) Award2003
  • Best Doctors in America2007 - 2016
  • WUMS Distinguished Investigator Award2008
  • NASPGHAN Foundation Mid-Level Career Development Award2015

Selected Publications view all (40)


Publication Co-Authors

1.
Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2017;64(2):210-217. PMCID:PMC5250572  PMID:27496798 
2.
Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr. 2016;63(3):357-64. PMCID:PMC4992416  PMID:27367788 
3.
Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417 
4.
Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-127. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735 
5.
Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015;61(1):94-101. doi:10.1097/MPG.0000000000000753  PMID:25651489 
6.
Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306(10):G893-902. doi:10.1152/ajpgi.00337.2013  PMCID:PMC4024724  PMID:24699334 
7.
Elucidating the metabolic regulation of liver regeneration. Am J Pathol. 2014;184(2):309-21. PMCID:PMC3906487  PMID:24139945 
8.
Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition. Epigenetics. 2014;9(11):1521-31. doi:10.4161/15592294.2014.983371  PMID:25482284 
9.
Pregnancy in an NTBC-treated patient with hereditary tyrosinemia type I. J Pediatr Gastroenterol Nutr. 2013. doi:10.1097/MPG.0b013e3182a27463  PMID:23838819 
10.
Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology. 2013;57(5):1742-51. doi:10.1002/hep.26206  PMID:23258575 
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