Schwartz, Alan L., Ph.D., M.D.  schwartz@wustl.edu

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Hematology and Oncology

phone: (314) 454-6018

Licensure and Board Certification

  • MA, Medical License 1977
  • Diplomate of the American Board of Pediatrics 1981
  • MO, Medical License 1986

Honors

  • University Book Prize in Biology, Case Western Reserve University1970
  • Alpha Omega Alpha, Case Western Reserve University School of Medicine1975
  • John L. Caughey, M.D. Award for Clinical Investigation, Case Western Reserve University School of Medicine1975
  • Bronze Medal of the Royal Humane Society of New Zealand1976
  • Upjohn Award in Clinical Pharmacology, Case Western Reserve University School of Medicine1976
  • George von L. Meyer Award, Children's Hospital Medical Center1977
  • Sidney Farber House Staff Prize, Children's Hospital Medical Center1978
  • David Abraham Fellowship in Pediatric Hematology and Oncology1979
  • Bushrod H. Campbell and Adah F. Hall Medical Foundation Fellow1980 - 1982
  • Outstanding Young Investigator, Boston Blood Club1981
  • John A. and George Hartford Foundation Fellow1982 - 1985
  • Society for Pediatric Research, Young Investigator Award1983
  • Established Investigator, American Heart Association1985 - 1990
  • Alumni Endowed Professor of Pediatrics, Washington University School of Medicine1987 - 1998
  • Gold Metal Award, Hospital Association of Greater St. Louis1988
  • Teacher of the Year, Washington University School of Medicine1988
  • Basil O'Connor Award, March of Dimes1990 - 1995
  • Outstanding Clinical Teacher 1990-1991, St. Louis Children's Hospital1991
  • Distinguished Visiting Professor, University of Utrecht School of Medicine, Utrecht, The Netherlands1993 - 1998
  • E. Mead Johnson Award1993
  • Distinguished Service Teaching Award, Washington University School of Medicine1993
  • Who's Who in Midwest1994 - 2002
  • Distinguished Service Teaching Award, Washington University School of Medicine1994
  • Harriet B. Spoehrer Professor of Pediatrics, Washington University School of Medicine1995 - 2016
  • Who's Who in American Education1995 - Pres
  • United States Patent 5,474,766 for Methods and Compositions for Inhibition of Hepatic Clearance of Tissue Type Plasminogen Activator, Docket Number C00108/059407 (issued December 12)1995
  • Who's Who in America1996 - 2010
  • Fellows Award, Barnes-Jewish Hospital Foundation1996
  • United States Patent 5,650,391 for Methods and Compositions for Inhibition of Hepatic Clearance of Tissue Factor Pathway Inhibitor (issued July 22)1997
  • Elected to National Academy of Medicine (Formally Institute of Medicine, National Academy of Sciences, U.S.A.)1999 - Pres
  • Who's Who in Medicine and Healthcare2001 - Pres
  • Best Doctors in America2003 - 2010
  • American Men and Women of Science2004
  • Who's Who Among America's Teachers2004 - Pres
  • Distinguished Faculty Award, Washington University School of Medicine2006
  • Elected Fellow, American Association for the Advancement of Science2007 - Pres
  • Best Doctors in America2007 - 2010
  • Fellows Award, Academy of Science – St. Louis2010
  • Doctor Medicinae et Chirurgiae Honoris Causa, University of Helsinki, Finland (Honorary Degree)2010
  • Distinguished Alumni Award, Case Western Reserve University2017

Selected Publications view all (231)


Publication Co-Authors

1.
Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α. J Cell Physiol. 2015;230(4):842-52. doi:10.1002/jcp.24812  PMCID:PMC4596538  PMID:25204433 
2.
American Pediatric Society 2014 presidential address: the thrill of discovery (and other foundations of biomedical research). Pediatr Res. 2014;76(3):316-20. doi:10.1038/pr.2014.81  PMID:24937547 
3.
Commentary: physician-scientist attrition: stemming the tide through national networks for training and development. Acad Med. 2011;86(9):1071-2. doi:10.1097/ACM.0b013e318224fd75  PMID:21865903 
4.
The Future of Children's Health in the Genomic Era. Rambam Maimonides Med J. 2011;2(3):e0053. doi:10.5041/RMMJ.10053  PMCID:PMC3678796  PMID:23908811 
5.
Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem. 2010;285(51):40192-200. doi:10.1074/jbc.M110.131615  PMCID:PMC3001001  PMID:20713359 
6.
Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 2009;69(3):879-86. doi:10.1158/0008-5472.CAN-08-3379  PMCID:PMC2633434  PMID:19176371 
7.
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol. 2009;49:73-96. doi:10.1146/annurev.pharmtox.051208.165340  PMID:18834306 
8.
The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system. Proc Natl Acad Sci U S A. 2008;105(41):15690-5. doi:10.1073/pnas.0808373105  PMCID:PMC2560994  PMID:18836078 
9.
In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer. FASEB J. 2008;22(6):1694-701. doi:10.1096/fj.07-095000  PMID:18198216 
10.
Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism. Proc Natl Acad Sci U S A. 2008;105(9):3339-44. doi:10.1073/pnas.0800165105  PMCID:PMC2265166  PMID:18296633 
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