Pediatric Research

Jennifer N. Avari Silva, M.D. jennifersilva@wustl.edu

Associate Professor of Pediatrics, Cardiology

Biomedical Engineering School of Medicine Cardiology

phone: (314) 454-6095

Education

BA, Union College, 1997
MD, St. George's University School of Medicine, 2002

Training

Residency in Pediatrics, Miami Children's Hospital, 2002 - 2005
Fellowship in Pediatric Cardiology, Washington University School of Medicine/St. Louis Children's Hospital, 2005 - 2008
Fellow, Rudy Lab in Biomedical Engineering, Washington University in St Louis, 2006 - 2008
4th year Advanced Fellowshipin Pediatric and Adult Congenital Electrophysiology, Children's Hospital Boston/Harvard Medical School, 2008 - 2009
Leadless Pacemaker Implant, Medtronic, Inc, 2018 - 2018

Licensure and Board Certification

2002 - PresECFMG
2005 - 2008Missouri Board of Medicine
2005 - PresDiplomate, American Board of Pediatrics
2009 - PresMissouri Board of Medicine
2011 - 2014IL, Department of Financial and Professional Regulation Divisional of Professional Regulation
2012 - 2015MO, DEA
2012 - 2013MO, BNDD
2012 - PresAmerican Board of Pediatrics, Subboard of Pediatric Cardiology
2013 - 2014MO, Missouri State Board of Registration for the Healing Arts
2015 - 2025International Board of Heart Rhythm Examiners, Certified Electrophysiology Specialist--Pediatric Cardiology, certificate #: 192745

Honors and Awards

Best Poster, 18th Annual HHS SBIR/STTR Conference, 2016
Fellow, Heart Rhythm Society, 2016 - Pres
Fellow, American Heart Association, 2018 - Pres
Founder Nomination, Tech Startup Readiness Project, 2019
Innovator Award (Skandy Award), Skandalaris Center, 2019
World Zoroastrian Entrepreneuer, 2019
Finalist (Deamer Category), Moonshot Award, 2019
Top Doctor, St Louis, 2019 - Pres
Fellow, American College of Cardiology, 2020 - Pres

Selected Publications view all (51)

Publication Co-Authors

George F. Van Hare, M.D.

William Brinson Orr

David Balzer, M.D.

Avihu Z. Gazit, M.D.

Francis Sessions Cole, III, M.D.

1.	Rudokas MW, Patel MD, Bowman TM, Van Hare GF, Silva JNAS. Lead Advancement in Pediatric Patients with SelectSecure 3830 Pacing Leads Journal of Cardiology and Current Research. 2014.
2.	Silva JN, Erickson CC, Carter CD, Greene EA, Kantoch M, Collins KK, Miyake CY, Carboni MP, Rhee EK, Papez A, Anand V, Bowman TM, Van Hare GF, Participating Members of Pediatric and Congenital Electrophysiology Society (PACES). Management of pediatric tachyarrhythmias on mechanical support. Circ Arrhythm Electrophysiol. 2014. doi:10.1161/CIRCEP.113.000973 PMID:24987047
3.	Moore JP, Patel PA, Shannon KM, Albers EL, Salerno JC, Stein MA, Stephenson EA, Mohan S, Shah MJ, Asakai H, Pflaumer A, Czosek RJ, Everitt MD, Garnreiter JM, McCanta AC, Papez AL, Escudero C, Sanatani S, Cain NB, Kannankeril PJ, Bratincsak A, Mandapati R, Silva JN, Knecht KR, Balaji S. Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy. Heart Rhythm. 2014;11(7):1163-9. doi:10.1016/j.hrthm.2014.04.023 PMID:24751393
4.	Silva JN, VON Bergen NH, Dubin AM, Collins KK, Chen J, Bowman TM, Van Hare GF. Assessment of intrathoracic impedance algorithm in the pediatric and adult congenital population. Pacing Clin Electrophysiol. 2014. doi:10.1111/pace.12372 PMID:24646399
5.	Mills KI, Anderson J, Levy PT, Cole FS, Silva JN, Kulkarni S, Shinawi M. Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. Am J Med Genet A. 2013;161A(1):137-44. doi:10.1002/ajmg.a.35701 PMID:23239491
6.	Silva JN, Silva JR. Updates on the inherited cardiac ion channelopathies: from cell to clinical. Curr Treat Options Cardiovasc Med. 2012;14(5):473-89. doi:10.1007/s11936-012-0198-1 PMID:22865245
7.	Silva JN, Vashist S, Van Hare GF. 3:2 antegrade atrioventricular block with AV nodal reentrant tachycardia: what is the mechanism and where is the block? Pacing Clin Electrophysiol. 2012;35(7):877-9. doi:10.1111/j.1540-8159.2012.03420.x PMID:22553974
8.	Vashist S, Silva JN, Van Hare GF, Papez AL, Su WW, Rhee EK. Unusually high association of hypertrophic cardiomyopathy and complex heart defects in children with fasciculoventricular pathways. Pacing Clin Electrophysiol. 2012;35(3):308-13. doi:10.1111/j.1540-8159.2011.03274.x PMID:22242628
9.	Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y. Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy. Heart Rhythm. 2011;8(5):692-9. doi:10.1016/j.hrthm.2011.01.017 PMCID:PMC3096066 PMID:21232630
10.	Silva JN, Canter CE, Singh TP, Gauvreau K, Piercey GE, Berul CI, Smoot LB, Blume ED, Fynn-Thompson F, Almond CS. Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant. 2010;29(11):1226-30. doi:10.1016/j.healun.2010.06.004 PMID:20691612

1.	Lisa Roelle, Aarti S. Dalal, Nathan Miller, William B. Orr, George Van Hare, and Jennifer N. Avari Silva. The Impact of Direct to Consumer Wearables in Pediatric Electrophysiology Telehealth Clinics: A Real-World Case Series Cardiovasc Digit Health J. 2020. doi:10.1016/j.cvdhj.2020.09.005 PMCID:PMCID 7538375
2.	Khaldoun G Tarakji, Jennifer N A Silva, Lin Y Chen, Mintu P Turakhia, Marco V Perez, Zachi I Attia, Rod Passman, Adrienne Boissy, David J Cho, Maulik Majmudar, Neil Mehta, Elaine Y Wan, Mina K Chung. Digital Health and the Care of the Arrhythmia Patient; What Every Electrophysiologist Needs to Know Circ Arrhythm Electrophysiol . 2020. doi:10.1161/CIRCEP.120.007953 PMID:33021815
3.	William B Orr, Chad Stanley, Aarti Dalal, Bridget Zoeller, George F Van Hare, Jennifer N Avari Silva. Institutional experience of healthy pediatric patients presenting with atrial fibrillation who had an electrophysiology study Journal of Cardiac Surgery. 2020;35(5):1004-1009. doi:10.1111/jocs.14506 PMID:32163635
4.	JNA Silva, MB Privitera, MK Southworth, JR Silva. Development and Human Factors Considerations for Extended Reality Applications in Medicine: The Enhanced ELectrophysiology Visualization and Interaction System (ĒLVIS) Proceedings from the International Conference on Human-Computer Interaction. 2020;341-356.
5.	Jennifer N Avari Silva, Michael K Southworth, Walter M Blume, Christopher Andrews, George F Van Hare, Aarti S Dalal, Nathan Miller, Sandeep S Sodhi, Jonathan R Silva. First-In-Human Use of a Mixed Reality Display During Cardiac Ablation Procedures JACC: Clinical Electrophysiology. 2020. doi:10.1016
6.	Southworth MK, Silva JNA, Blume WM, Van Hare GF, Dalal AS, Silva JR. Performance Evaluation of Mixed Reality Display for Guidance during Transcatheter Cardiac Mapping and Ablation. IEEE Journal of Translational Engineering in Health and Medicine. 2020;(3):1-10. doi:10.1109/JTEHM.2020.3007031 PMCID:PMC7390021 PMID:32742821
7.	William B Orr, Bayley Roberts, Aarti Dalal, Jennifer N Avari Silva, George F Van Hare. Successful Institutional Development of a Pediatric Exercise Stress Testing Program after the Establishment of a Dedicated Exercise Team Journal of Exercise Physiology Online. 2020;23(3).
8.	Jennifer N Avari Silva, George F Van Hare. Catheter Ablation in Pediatric Congenital Heart Disease: A Modern Perspective Circ: A&E. 2019;12(11):e008019. doi:10.1161
9.	Southworth MK, Silva JR, Silva JNA. Use of Extended Realities in Cardiology Trends Cardiovasc Med. 2019.
10.	Andrews C, Southworth MK, Silva JNA, Silva JR. Extended Reality In Medical Practice Curr Treat Options Cardiovasc Med. 2019;21(4):18.
11.	Dubin AM, Jorgensen NW, Radbill AE, Bradley DJ, Silva JN, Tsao S, Kanter RJ, Tanel RE, Trivedi B, Young ML, Pflaumer A, McCormack J, Seslar SP. What have we learned in the last 20 years? A Comparison of a Modern Era Pediatric and Congenital Catheter Ablation Registry to Prior Pediatric Ablation Registries Heart Rhythm. 2019;16(1):57-63.
12.	Gropler MR, Dalal AS, Van Hare GF, Avari Silva JN. Can smartphone wireless ECGs be used to accurately assess ECG intervals in pediatrics? A comparison of mobile health monitoring to standard 12-lead ECG PLoS One . 2018;13(9).
13.	Silva JNA, Southworth M, Raptis C, Silva JR. Emerging Applications of Virtual Reality in Cardiovascular Medicine JACC BTS. 2018;3(3):420-430.
14.	Ambrose MB, Silva JNA, Rudokas M, Bowman TM, Murphy J, Van Hare GF. Pediatric coronary sinus morphology predicts supraventricular tachycardia substrate JICE. 2018;51(2):163-168.
15.	Papagiannis J, Beissel DJ, Krause U, Cabrera M, Telishevska M, Seslar A, Johnsrude C, Anderson C, Tisma-Dupanovic S, Connelly D, Avramidis D, Carter C, Kornyei L, Law I, Von Bergen N, Janusek J, Silva JNA, Rosenthal E, Willcox M, Kubus P, Hessling G, Paul T and for the Pediatric and Congenital Electrophysiology Society. Atrioventricular Nodal Reentrant Tachycardia in Patients With Congenital Heart Disease Outcome After Catheter Ablation Cric A&E. 2017;10:e004896.
16.	Nguyen HH, Law IH, Rudokas MW, Lampe J, Bowman TM, Van Hare GF, Avari Silva JN. . Reveal LINQ Versus Reveal XT Implantable Loop Recorders: Intra- and Post-Procedural Comparison. J Pediatr. 2017.
17.	Dalal AS, Nguyen HH, Bowman T, Van Hare GF, Avari Silva JN.. Force-Sensing Catheters During Pediatric Radiofrequency Ablation: The FEDERATION Study. JAHA. 2017.
18.	Kim H, Wolff J, Dalal A, Van Hare GF, Avari Silva JN. . Use of IV Sotalol in Newborns with SVT. Heart Rhythm: Case Reports.. 2017.
19.	Papagiannis J, Beissel DJ, Krause U, Cabrera M, Telishevska M, Seslar A, Johnsrude C, Anderson C, Tisma-Dupanovic S, Connelly D, Avramidis D, Carter C, Kornyei L, Law I, Von Bergen N, Janusek J, Silva JNA, Rosenthal E, Willcox M, Kubus P, Hessling G, Paul T and for the Pediatric and Congenital Electrophysiology Society. . Atrioventricular Nodal Reentrant Tachycardia in Patients With Congenital Heart Disease Outcome After Catheter Ablation. Circ: A&E.. 2017.
20.	Moore JP, Wang S, Albers EL, Salerno JC, Stephenson EA, Shah MJ, Pflaumer A, Czosek RJ, Garnreiter JM, Collins K, Papez AL, Sanatani S, Cain NB, Kannankeril PJ, Perry JC, Mandapati R, Silva JN, Balaji S, Shannon KM. A Clinical Risk Score to Improve the Diagnosis of Tachycardia-Induced Cardiomyopathy in Childhood. Am J Cardiol. 2016;118(7):1074-80. PMID:27515893
21.	Nguyen HH, Shahanavaz S, Van Hare GF, Balzer DT, Nicolas R, Avari SIlva JN. Percutaneous Pulmonary Valve Implantation Alters Electrophysiologic Substrate J Am Heart Assoc. 2016;5(10). doi:10.1161/JAHA.116.004325 PMCID:PMC5121524 PMID:27694326
22.	Avari Silva JN, Bromberg BI, Emge FK, Bowman TM, Van Hare GF. Implantable Loop Recorder Monitoring for Refining Management of Children With Inherited Arrhythmia Syndromes. J Am Heart Assoc. 2016;5(6). PMCID:PMC4937287 PMID:27231019
23.	Lehman GC, Van Hare GF, Silva JNA. . Atrial Tachycardia in an Electrically Dissociated Native Right Atrium after Heart Transplantation. Heart Rhythm Case Reports. 2016.
24.	Dykes JC, Al-mousily MF, Abuchaibe EC, Silva JN, Zadinsky J, Duarte D, Welch E. The incidence of chromosome abnormalities in neonates with structural heart disease Heart. 2016;102(8):634-7. doi:10.1136/heartjnl-2015-308650 PMID:26843533
25.	Nguyen HH, Van Hare GF, Rudokas M, Bowman T, Silva JN. SPEAR Trial: Smartphone Pediatric ElectrocARdiogram Trial. PLoS One. 2015;10(8):e0136256. PMCID:PMC4546652 PMID:26295569
26.	Rockefeller TA, Silva JNA, Liao S, Vichharajani A. . Corrected QT prolongation and bradycardia during therapeutic hypothermia in an infant: a case report NoeReviews. 2015.
27.	Zhang J, Sacher F, Hoffmayer K, O'Hara T, Strom M, Cuculich P, Silva J, Cooper D, Faddis M, Hocini M, Haïssaguerre M, Scheinman M, Rudy Y. Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients. Circulation. 2015;131(22):1950-9. PMCID:PMC4452400 PMID:25810336
28.	Vijayakumar R, Silva JNA, Desouza KA, Abraham RL, Strom M, Sacher F, Van Hare GF, Haïssaguerre M, Roden DM, Rudy Y. Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI). Circulation. 2014;130(22):1936-1943. PMCID:PMC4245321 PMID:25294783
29.	Rudokas MW, Patel MD, Bowman TM, Van Hare GF, Silva JNAS. Lead Advancement in Pediatric Patients with SelectSecure 3830 Pacing Leads Journal of Cardiology and Current Research. 2014.
30.	Silva JN, Erickson CC, Carter CD, Greene EA, Kantoch M, Collins KK, Miyake CY, Carboni MP, Rhee EK, Papez A, Anand V, Bowman TM, Van Hare GF, Participating Members of Pediatric and Congenital Electrophysiology Society (PACES). Management of pediatric tachyarrhythmias on mechanical support. Circ Arrhythm Electrophysiol. 2014. doi:10.1161/CIRCEP.113.000973 PMID:24987047
31.	Moore JP, Patel PA, Shannon KM, Albers EL, Salerno JC, Stein MA, Stephenson EA, Mohan S, Shah MJ, Asakai H, Pflaumer A, Czosek RJ, Everitt MD, Garnreiter JM, McCanta AC, Papez AL, Escudero C, Sanatani S, Cain NB, Kannankeril PJ, Bratincsak A, Mandapati R, Silva JN, Knecht KR, Balaji S. Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy. Heart Rhythm. 2014;11(7):1163-9. doi:10.1016/j.hrthm.2014.04.023 PMID:24751393
32.	Silva JN, VON Bergen NH, Dubin AM, Collins KK, Chen J, Bowman TM, Van Hare GF. Assessment of intrathoracic impedance algorithm in the pediatric and adult congenital population. Pacing Clin Electrophysiol. 2014. doi:10.1111/pace.12372 PMID:24646399
33.	Mills KI, Anderson J, Levy PT, Cole FS, Silva JN, Kulkarni S, Shinawi M. Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. Am J Med Genet A. 2013;161A(1):137-44. doi:10.1002/ajmg.a.35701 PMID:23239491
34.	Silva JN, Silva JR. Updates on the inherited cardiac ion channelopathies: from cell to clinical. Curr Treat Options Cardiovasc Med. 2012;14(5):473-89. doi:10.1007/s11936-012-0198-1 PMID:22865245
35.	Silva JN, Vashist S, Van Hare GF. 3:2 antegrade atrioventricular block with AV nodal reentrant tachycardia: what is the mechanism and where is the block? Pacing Clin Electrophysiol. 2012;35(7):877-9. doi:10.1111/j.1540-8159.2012.03420.x PMID:22553974
36.	Vashist S, Silva JN, Van Hare GF, Papez AL, Su WW, Rhee EK. Unusually high association of hypertrophic cardiomyopathy and complex heart defects in children with fasciculoventricular pathways. Pacing Clin Electrophysiol. 2012;35(3):308-13. doi:10.1111/j.1540-8159.2011.03274.x PMID:22242628
37.	Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y. Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy. Heart Rhythm. 2011;8(5):692-9. doi:10.1016/j.hrthm.2011.01.017 PMCID:PMC3096066 PMID:21232630
38.	Silva JN, Canter CE, Singh TP, Gauvreau K, Piercey GE, Berul CI, Smoot LB, Blume ED, Fynn-Thompson F, Almond CS. Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant. 2010;29(11):1226-30. doi:10.1016/j.healun.2010.06.004 PMID:20691612
39.	Collins KK, Silva JN, Rhee EK, Schaffer MS. Use of a wearable automated defibrillator in children compared to young adults. Pacing Clin Electrophysiol. 2010;33(9):1119-24. doi:10.1111/j.1540-8159.2010.02819.x PMID:20561227
40.	Silver ES, Silva JN, Ceresnak SR, Chiesa NA, Rhee EK, Dubin AM, Avasarala K, Van Hare GF, Collins KK. Cryoablation with an 8-mm tip catheter for pediatric atrioventricular nodal reentrant tachycardia is safe and efficacious with a low incidence of recurrence. Pacing Clin Electrophysiol. 2010;33(6):681-6. doi:10.1111/j.1540-8159.2010.02706.x PMID:20230479
41.	Silva JN, Canter CE. Current management of pediatric dilated cardiomyopathy. Curr Opin Cardiol. 2010;25(2):80-7. doi:10.1097/HCO.0b013e328335b220 PMID:20019605
42.	Silva JN, Van Hare G. Management of postoperative pediatric cardiac arrhythmias: current state of the art. Curr Treat Options Cardiovasc Med. 2009;11(5):410-6. PMID:19846040
43.	Collins KK, Van Hare GF, Kertesz NJ, Law IH, Bar-Cohen Y, Dubin AM, Etheridge SP, Berul CI, Avari JN, Tuzcu V, Sreeram N, Schaffer MS, Fournier A, Sanatani S, Snyder CS, Smith RT Jr, Arabia L, Hamilton R, Chun T, Liberman L, Kakavand B, Paul T, Tanel RE. Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies. J Am Coll Cardiol. 2009;53(8):690-7. doi:10.1016/j.jacc.2008.11.019 PMID:19232902
44.	Ghosh S, Avari JN, Rhee EK, Woodard PK, Rudy Y. Hypertrophic cardiomyopathy with preexcitation: insights from noninvasive electrocardiographic imaging (ECGI) and catheter mapping. J Cardiovasc Electrophysiol. 2008;19(11):1215-7. doi:10.1111/j.1540-8167.2008.01203.x PMCID:PMC2631093 PMID:18479334
45.	Avari JN, Rhee EK. Cardiac resynchronization therapy for pediatric heart failure. Heart Rhythm. 2008;5(10):1476-8. doi:10.1016/j.hrthm.2008.05.024 PMID:18672406
46.	Ghosh S, Rhee EK, Avari JN, Woodard PK, Rudy Y. Cardiac memory in patients with Wolff-Parkinson-White syndrome: noninvasive imaging of activation and repolarization before and after catheter ablation. Circulation. 2008;118(9):907-15. doi:10.1161/CIRCULATIONAHA.108.781658 PMCID:PMC2747627 PMID:18697818
47.	Avari JN, Rhee EK. Markers of coronary sinus accessory pathways in pediatrics. Pacing Clin Electrophysiol. 2008;31(8):968-73. doi:10.1111/j.1540-8159.2008.01123.x PMID:18684252
48.	Ghosh S, Avari JN, Rhee EK, Woodard PK, Rudy Y. Noninvasive electrocardiographic imaging (ECGI) of epicardial activation before and after catheter ablation of the accessory pathway in a patient with Ebstein anomaly. Heart Rhythm. 2008;5(6):857-60. doi:10.1016/j.hrthm.2008.03.011 PMCID:PMC2967218 PMID:18482872
49.	Avari JN, Jay KS, Rhee EK. Experience and results during transition from radiofrequency ablation to cryoablation for treatment of pediatric atrioventricular nodal reentrant tachycardia. Pacing Clin Electrophysiol. 2008;31(4):454-60. doi:10.1111/j.1540-8159.2008.01033.x PMID:18373764
50.	Ghosh S, Avari JN, Rhee EK, Woodard PK, Rudy Y. Noninvasive electrocardiographic imaging (ECGI) of a univentricular heart with Wolff-Parkinson-White syndrome. Heart Rhythm. 2008;5(4):605-8. doi:10.1016/j.hrthm.2007.12.018 PMCID:PMC2329801 PMID:18325851
51.	Gazit AZ, Avari JN, Balzer DT, Rhee EK. Electrocardiographic diagnosis of myocardial ischemia in children: is a diagnostic electrocardiogram always diagnostic? Pediatrics. 2007;120(2):440-4. doi:10.1542/peds.2007-0170 PMID:17671071