Philip C. Spinella, M.D., FCCM  pspinella@wustl.edu

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Director, Critical Care Translational Research Program
Professor of Pediatrics, Critical Care Medicine
Critical Care MedicinePediatric Research

phone: (314) 454-2527

Research Interests

Dr. Spinella’s research program focuses on examining the biologic consequences of blood product manufacturing by both exploring mechanisms in the lab and performing clinical trials to determine clinical relevance. The laboratory has developed a unique microfluidic assay of hemostasis that simulates bleeding. This assay is primary used to characterize the coagulopathy associated with multiple etiologies and the hemostatic response of different blood products according to the etiology or mechanisms of coagulopathy. The laboratory is also currently focused on mechanisms associated with the platelet storage lesion and how platelet storage temperature affects it. Dr. Spinella is also leading an international randomized controlled trial to examine the efficacy and safety of cold stored platelets compared to room temperature platelets for complex cardiac surgery patients with active bleeding. He is a co-founder of Kalocyte which is developing a freeze dried artificial red cell and working with other industries to examine the efficacy and safety of dried plasma, improved RBC storage solutions, and nanoparticle based hemostatic agents that facilitate platelet adhesion and aggregation. Dr. Spinella has also established transfusion and hemostasis focused research networks to include the Pediatric Critical Care Blood Research Network and the Trauma Hemostasis and Oxygenation Research (THOR) Network.

Education

  • BS, Tufts University1991
  • MD, New York Medical College1995

Training

  • Pediatric Internship, Tripler Army Medical Center1995 - 1996
  • Pediatric Residency, Tripler Army Medical Center1996 - 1998
  • Pediatric Critical Care Fellowship, Children’s Hospital of Philadelphia2000 - 2003

Licensure and Board Certification

  • 1998Pediatrics
  • 2004Pediatric Critical Care

Honors and Awards

  • Junior Alpha Omega Alpha1995
  • 1st Place Best, Critical Care Abstract Award, High Fidelity Medical Simulation as a method to assess retention of resuscitative skills, AAP National Conference2006
  • 2nd Place, Best Abstract, Blood product replacement effects survival in patients with massive transfusion at a combat support hospital. International Military Trauma Symposium. Koblenz, Germany2006
  • Faculty Teaching Award, Wilford Hall Medical Center, San Antonio, TX2006
  • Trauma Specialty Award, SCCM 2008, Oral presentation of “Effect of blood products on mortality in combat casualties”2007
  • Trauma Specialty Award, SCCM 2009, Oral presentation of “Whole blood improves survival compared to component therapy in trauma patients”2008
  • US Army best invention award for development of hemostatic resuscitation concept for patients with traumatic injuries2008
  • Best Abstract Citation Award, Society of Critical Care Medicine Symposium 2009. “A prospective randomized cross-over trial of repetitive simulation for pediatric critical illness”2009
  • Research Citation Finalist, Society of Critical Care Medicine Symposium 2010. Association between length of storage of red blood cell units and outcome of critically ill children in the TRIPICU study2009
  • Research Citation Finalist, Society of Critical Care Medicine Symposium 2010. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients2009
  • Faculty Award for Excellence in Teaching Acute Care, University of Connecticut Pediatric Residency Program2010
  • Presidential Citation Award, Society of Critical Care Medicine2011
  • Presidential Citation Award, Society of Critical Care Medicine2012

Selected Publications view all (216)


1.
2016 Military Supplement Tactical Study of Care Originating in the Prehospital Environment (TACSCOPE): Acute Traumatic Coagulopathy on the Contemporary Battlefield. Shock. 2016. PMID:27405067 
2.
Adipose tissue location and contribution to postinjury hypercoagulability. J Trauma Acute Care Surg. 2016. doi:10.1097/TA.0000000000001096  PMID:27120319 
3.
"Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion. 2016;56 Suppl 2:S182-9. doi:10.1111/trf.13500  PMID:27100755 
4.
A proposed field emergency donor panel questionnaire and triage tool. Transfusion. 2016;56 Suppl 2:S119-27. doi:10.1111/trf.13487  PMID:27100748 
5.
Dried plasma: state of the science and recent developments. Transfusion. 2016;56 Suppl 2:S128-39. doi:10.1111/trf.13580  PMID:27100749 
6.
RDCR Symposium fifth-year anniversary edition: global prehospital care rooted in a history of military innovation. Transfusion. 2016;56 Suppl 2:S107-9. doi:10.1111/trf.13606  PMID:27100745 
7.
Whole blood for hemostatic resuscitation of major bleeding. Transfusion. 2016;56 Suppl 2:S190-202. doi:10.1111/trf.13491  PMID:27100756 
8.
Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016;56 Suppl 1:S65-75. doi:10.1111/trf.13532  PMID:27001364 
9.
Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. doi:10.1111/petr.12673  PMID:26899454 
10.
The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016;56 Suppl 1:S52-64. doi:10.1111/trf.13455  PMID:27001362