Philip C. Spinella, M.D., FCCM  spinella_p@kids.wustl.edu

Director, Critical Care Translational Research Program
Researcher, Patient Oriented Research Unit
Critical Care MedicinePatient Oriented Research Unit

phone: (314) 454-2527

Research Interests

Dr. Philip C. Spinella is the Director of the Pediatric Critical Care Translational Research Program at St. Louis Children's Hospital and Associate Professor of Pediatrics at Washington University School of Medicine. Dr. Spinella earned his Bachelor of Arts degree in Biology (1991) at Tufts University, and his Medical Degree (1995 at New York Medical College. Following residency in Pediatrics at Tripler Army Medical Center in Honolulu, HI, he served as Chief of Pediatric In-patient and Outpatient Services at Bayne-Jones Army Medical Center at Fort Polk, LA (1998-2000). Dr. Spinella then completed a fellowship in Pediatric Critical Care at the Children's Hospital of Philadelphia (2003). After fellowship he served as the Assistant Chief of Pediatric Critical Care at Wilford Hall Medical Center in San Antonio (2003-2007). During this time he was deployed to Iraq during Operation Iraqi Freedom for one year (2004-2005). It was during this deployment that Dr. Spinella's interest in the efficacy and safety of blood products for the treatment of shock and coagulopathy developed. Since this experience he has developed a research program that focuses on understanding the mechanisms related to adverse events secondary to the transfusion of blood products and performing clinical trials to determine the efficacy and safety of blood products. He came to Washington University in 2010 to assume leadership of the Pediatric Critical Care Translational Research Program. Dr. Spinella served 15 years in the US Army and separated as a Lieutenant Colonel in 2007. He is a veteran of the Iraq War, where he received a Bronze Star and the Combat Medic Badge for providing care under fire. In collaboration with investigators at the US Army Institute of Surgical Research, his groundbreaking work in the area of treatment of hemorrhagic shock received the US Army's Best Invention Award in 2007 for his role in the development of the concept of "damage control resuscitation". Dr. Spinella co-founded and is the co-Chair of the Trauma Hemostasis and Oxygenation Research (THOR) Network, which is an international multidisciplinary network of civilian and military providers ranging from first responders/medics to critical care physicians, as well as from basic scientists to clinical trialists. Since 2011, THOR has organized and sponsored a Remote Damage Control Resuscitation annual conference with civilian and military attendees encompassing 18 countries. The conference has led to national policy changes regarding the care of patients with traumatic hemorrhagic shock in the pre-hospital phase of resuscitation in countries such as Israel, Australia, Canada, France, Norway, and the United Kingdom, as well as policy changes at multiple trauma centers in the US. Dr. Spinella is a consultant to the US Army Blood Research Program at the US Army Institute of Surgical Research, and the Norwegian Navy Blood Research Program. He has organized a full day conference at the White House for the National Security Service after the Boston Marathon bombing in response to the concern for an adequate blood supply for large terrorist attacks that cause a significant number of casualties with hemorrhagic shock. This responsibility was based on his experience consulting for the Committee on Emergency Preparedness led by Homeland Security and the Public Health Service for the Northeast Region from 2006-2008. In addition, he has also briefed the US Department of Defense on advancements in the area of trauma resuscitation. In 2015, Dr. Spinella was appointed by the Institute of Medicine as a member on the Committee of Military Trauma Care's Learning Health System and its Translation to the Civilian Sector. Dr. Spinella is also a co-founder and Chair of the Pediatric Critical Care Blood Research Network (Blood Net). Blood Net is an international network of approximately 90 members from 4 countries with a mission to improve outcomes in critically ill children by supporting and performing research in transfusion medicine, hemostasis and blood management. Dr. Spinella is a well-established investigator who ahs been awarded approximately 20 million dollars in funding from the US Department of Defense and the National Institutes of Health. Currently he is a Principal Investigator of 2 randomized controlled trials. The ABC-PICU trial examines the effect of RBC storage age on outcomes in critically ill children. The TAMPITI trial examines the immunologic effect of tranexamic acid in patients with severe traumatic injuries.

Education

  • BS, Tufts University1991
  • MD, New York Medical College1995

Training

  • Pediatric Internship, Tripler Army Medical Center1995 - 1996
  • Pediatric Residency, Tripler Army Medical Center1996 - 1998
  • Pediatric Critical Care Fellowship, Children’s Hospital of Philadelphia2000 - 2003

Licensure and Board Certification

  • Pediatrics 1998
  • Pediatric Critical Care 2004

Honors

  • Junior Alpha Omega Alpha1995
  • 1st Place Best, Critical Care Abstract Award, High Fidelity Medical Simulation as a method to assess retention of resuscitative skills, AAP National Conference2006
  • 2nd Place, Best Abstract, Blood product replacement effects survival in patients with massive transfusion at a combat support hospital. International Military Trauma Symposium. Koblenz, Germany2006
  • Faculty Teaching Award, Wilford Hall Medical Center, San Antonio, TX2006
  • Trauma Specialty Award, SCCM 2008, Oral presentation of “Effect of blood products on mortality in combat casualties”2007
  • Trauma Specialty Award, SCCM 2009, Oral presentation of “Whole blood improves survival compared to component therapy in trauma patients”2008
  • US Army best invention award for development of hemostatic resuscitation concept for patients with traumatic injuries2008
  • Best Abstract Citation Award, Society of Critical Care Medicine Symposium 2009. “A prospective randomized cross-over trial of repetitive simulation for pediatric critical illness”2009
  • Research Citation Finalist, Society of Critical Care Medicine Symposium 2010. Association between length of storage of red blood cell units and outcome of critically ill children in the TRIPICU study2009
  • Research Citation Finalist, Society of Critical Care Medicine Symposium 2010. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients2009
  • Faculty Award for Excellence in Teaching Acute Care, University of Connecticut Pediatric Residency Program2010
  • Presidential Citation Award, Society of Critical Care Medicine2011
  • Presidential Citation Award, Society of Critical Care Medicine2012

Selected Publications view all (133)


1.
2016 Military Supplement Tactical Study of Care Originating in the Prehospital Environment (TACSCOPE): Acute Traumatic Coagulopathy on the Contemporary Battlefield. Shock. 2016. PMID:27405067 
2.
Adipose tissue location and contribution to postinjury hypercoagulability. J Trauma Acute Care Surg. 2016. doi:10.1097/TA.0000000000001096  PMID:27120319 
3.
"Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion. 2016;56 Suppl 2:S182-9. doi:10.1111/trf.13500  PMID:27100755 
4.
A proposed field emergency donor panel questionnaire and triage tool. Transfusion. 2016;56 Suppl 2:S119-27. doi:10.1111/trf.13487  PMID:27100748 
5.
Dried plasma: state of the science and recent developments. Transfusion. 2016;56 Suppl 2:S128-39. doi:10.1111/trf.13580  PMID:27100749 
6.
RDCR Symposium fifth-year anniversary edition: global prehospital care rooted in a history of military innovation. Transfusion. 2016;56 Suppl 2:S107-9. doi:10.1111/trf.13606  PMID:27100745 
7.
Whole blood for hemostatic resuscitation of major bleeding. Transfusion. 2016;56 Suppl 2:S190-202. doi:10.1111/trf.13491  PMID:27100756 
8.
Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016;56 Suppl 1:S65-75. doi:10.1111/trf.13532  PMID:27001364 
9.
Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. doi:10.1111/petr.12673  PMID:26899454 
10.
The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016;56 Suppl 1:S52-64. doi:10.1111/trf.13455  PMID:27001362 
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