Investigators in the Department of Pediatrics at Washington University hold many NIH-supported grants. Larger, multicenter projects are:
Child Health Research Center
The Department of Pediatrics at Washington University School of Medicine has received a five year renewal of its designation as a Child Health Research Center of Excellence by the National Institutes of Health. This Center, supported by a $2 million grant, is using models developed at the Center to study pathology of diseases that affect children. With this center, which focuses on human developmental biology, we have the ability both to understand the pathology of the diseases, as well as to evaluate new treatments that eventually will benefit children. More information is available on the CHRC web site. The principal investigator for this project is Dr. Alan Schwartz.
Sleep And Asthma Cohort (SAC) Study
The Sickle Cell Anemia Sleep & Asthma Cohort Study (SAC) is a research study that will try to determine how asthma, with or without low levels of oxygen during sleep, causes an increase in pain episodes or lung complications in children with sickle cell anemia.
This four-year observational study involves three sites in the United States and England. The study is funded by a $7.9 million National Institutes of Health grant, awarded to Washington University School of Medicine in St. Louis, serving as the lead clinical center with Robert C. Strunk, MD, Donald Strominger Professor of Pediatrics as Principal Investigator with Dr. Michael Debaun as the coordinating center at Vanderbilt University. More information can be found on the SAC website.
Hirschsprung Disease Study
Dr. Robert Heuckeroth is leading a study to learn more about the underlying causes of Hirschsprung disease, a birth defect where the enteric nervous system (ENS) is missing from the end of the bowel. The ENS is the part of the nervous system that controls intestinal activity and when the ENS is missing, the bowel does not work properly. Hirschsprung disease is a genetic disorder that can cause severe illness. We are trying to find new ways to treat and prevent Hirschsprung disease. More information about Hirschsprung disease and our human research studies can be found at our website.
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