Pediatric Research

Brian DeBosch, M.D., Ph.D. deboschb@wustl.edu

Diabetes Research Center

View my lab

Cell Biology & Physiology Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Education

BS, Summa Cum Laude Distinction, University of Michigan, 2001
MD, Washington University School of Medicine, 2008
PhD, Olin Fellowship, Washington University School of Medicine, 2008

Training

Residency, St. Louis Children's Hospital, 2008 - 2010
Fellowship - Accelerated Research Pathway, Washington University School of Medicine, 2010 - 2014

Licensure and Board Certification

2008 - PresBasic Life Support
2008 - 2010Neonatal Resuscitation Program
2008 - 2010Pediatric Advanced Life Support
2013 - PresAmerican Board of Pediatrics
2015 - PresMO, Physician & Surgeon License
2015 - PresAmerican Board of Pediatrics (ABP), Pediatric Gastroenterology, Hepatology & Nutrition

Honors and Awards

National Merit Scholar, 1997
Regents-Alumni Scholar, University of Michigan, Ann Arbor, 1997
UPAAM Outstanding Youth of Michigan Scholar, 1997
Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor, 1997 - 2001
Ford Endowed Merit Scholar, 1997 - 2001
James B. Angell Scholar, University of Michigan, Ann Arbor, 1997 - 2001
Class Honors Award, University of Michigan, Ann Arbor, 1998 - 2001
Sophomore Honors Award, University of Michigan, Ann Arbor, 1999
Telluride Association Scholar, 1999 - 2001
Barry M. Goldwater Scholar, 2000 - 2001
Delta Phi Alpha National German Honor Society, 2001 - Pres
National Council on Undergraduate Research Award, 2001
Highest Honors Thesis Distinction, University of Michigan, Ann Arbor, 2001 - 2001
Summa Cum Laude, University of Michigan, Ann Arbor, 2001 - 2001
Triple Crown Award - St. Louis Children's Hospital, 2011
Digestive Diseases Research Center P&F Award, 2013 - 2015
Faculty Scholar - Children's Discovery Institute, 2014 - Pres
Scholar - Child Health Research Center of Washington University School of Medicine, 2014 - Pres
Early Investigator Award - the Endocrine Society, 2015 - Pres
St. Louis Children's Hospital Recognition Award, 2015
United States Department of Defense Discovery Award, 2017 - Pres
Inductee, Society for Pediatric Research, 2018 - Pres
Triple Crown Award - St. Louis Children's Hospital, 2018 - 2018
Co-Inventor (Paul Hruz, MD, PhD), LEAP Inventor Challenge - Washington University School of Medicine Skandalaris Center: "Novel Treatment of Fatty Liver Disease", 2018 - Pres
Doris Duke Charitable Foundation Clinical Scientist Development Award, 2019 - Pres
Early Career Reviewer - NIH / CSR, 2020 - 2020
AGA Institute Research Awards Panel, 2020 - Pres
AASLD Pilot Research Award, 2020 - 2021

Selected Publications view all (34)

Publication Co-Authors

Misty Good, M.D., M.S.

Phillip I. Tarr, M.D.

Kristine Wylie, Ph.D.

Michael Thompson

Todd N. Wylie

Paul W. Hruz, M.D., Ph.D.

1.	DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640 PMID:26905426
2.	Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727 PMCID:PMC4527419 PMID:24803506
3.	DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642 PMCID:PMC4348061 PMID:25100214
4.	Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002 PMCID:PMC4036240 PMID:24519932
5.	DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137 PMCID:PMC3805847 PMID:24030250
6.	DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541 PMCID:PMC3423610 PMID:22822162
7.	Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011 PMCID:PMC2975863 PMID:20728450
8.	Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920 PMCID:PMC2913227 PMID:20360254
9.	DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328
10.	DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008 PMCID:PMC2442827 PMID:18423486

1.	McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN. Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab. 2020;2(11):1232-1247. PMID:33106690
2.	Robert N. Helsley, Francois Moreau, Manoj K. Gupta, Aurelia Radulescu, Brian DeBosch, Samir Softic. Tissue-Specific Fructose Metabolism in Obesity and Diabetes Curr Diab Rep. 2020;20:64. doi:10.1007/s11892-020-01342-8
3.	Kading J, Finck BN, DeBosch BJ. Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction. FEBS. 2020. doi:doi: 10.1111/febs.15482 PMID:32654397
4.	Zhang Y and DeBosch BJ. Microbial and metabolic impacts of trehalose and trehalose analogues Gut Microbes. 2020;24:1-8. doi:doi: 10.1080/19490976.2020.1750273 PMID:32329657
5.	Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI and DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice Gastroenterology. 2020;158(5):1402-1416.e2. doi:doi: 10.1053/j.gastro.2019.11.295 PMCID:PMC7103499
6.	Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2020;158(5):1402-1416.e2. PMCID:PMC7103499 PMID:31838076
7.	Zhang Y and DeBosch BJ. Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms Curr Opin Clin Nutr Metab Care. 2019;22(4):303-310. doi:10.1097/MCO.0000000000000568 PMID:31033580
8.	Xie Y, Matsumoto H, Kennedy S, Newberry EP, Moritz W, DeBosch BJ, Moley KH, Rubin DC, Warner BW, Kau AL, Tarr PI, Wylie TN, Wylie KM, Davidson NO. Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations. Hepatology. 2019;70(4):1168-1184. doi:10.1002/hep.30669 PMCID:PMC6783349 PMID:31004524
9.	Zhang Y, Higgins CB, Fortune HM, Chen P, Stothard AI, Swarts BM, DeBosch BJ. Hepatocyte Arginase 2 is sufficient to convey the therapeutic metabolic effects of fasting Nature Communications. 2019;10:1587. doi:0.1038/s41467-019-09642-8 PMCID:PMC6453920 PMID:30962478
10.	Danielson ND, Collins J, Stothard AI, Dong Q, Kalera K, Woodruff P, DeBosch BJ, Britton RA, Swarts BM . Degradation-Resistant Trehalose Analogues Block Utilization of Trehalose by Hypervirulent Clostridioides difficile Chem Comm. 2019;55(34):5009-5012. doi:10.1039/C9CC01300H PMCID:PMC6499371 PMID:30968891
11.	Berna AZ, DeBosch B, Stoll J, John ARO. Breath Collection from Children for Disease Biomarker Discovery J. Vis. Exp.. 2019; 144:e59217. doi:10.3791/59217 PMCID:PMC6596991 PMID:30829338
12.	Ferey J, Boudoures A, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, and Moley KH. Maternal High-Fat, High-Sucrose Diet Induces Transgenerational Cardiac Mitochondrial Dysfunction Independent of Maternal Mitochondrial Inheritance AJP Heart Circ Physiol. 2019;316(5):H1202-H1210. doi:10.1152/ajpheart.00013.2019 PMCID: PMC6580388 PMID:30901280
13.	Bauckman KA, Matsuda R, Higgins CB, DeBosch BJ, Wang C, Mysorekar IU. Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection. Am J Physiol Renal Physiol. 2019. doi:10.1152/ajprenal.00133.2018 PMCID:PMC6580250 PMID:30724105
14.	Higgins CB, Zhang Y, Mayer AL, Fujiwara H, Stothard AI, Graham MJ, Swarts BM, DeBosch BJ. Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. JCI Insight. 2018;3(16). PMCID:PMC6141168 PMID:30135298
15.	Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ. Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology. 2018;159(5):2110-2126. PMCID:PMC6366533 PMID:29596655
16.	Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani B, Graham MJ, Hruz PW, DeBosch BJ. Transcription Factor EB (TFEB)-dependent Induction of Thermogenesis by the Hepatocyte Solute Carrier 2A (SLC2A) inhibitor, Trehalose Autophagy. 2018;24(22):2959-1975. doi:10.1080/15548627.2018.1493044 PMCID:PMC6152536 PMID:29996716
17.	Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMCID:PMC5138640 PMID:27922102
18.	DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640 PMID:26905426
19.	Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727 PMCID:PMC4527419 PMID:24803506
20.	DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642 PMCID:PMC4348061 PMID:25100214
21.	Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002 PMCID:PMC4036240 PMID:24519932
22.	DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137 PMCID:PMC3805847 PMID:24030250
23.	DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541 PMCID:PMC3423610 PMID:22822162
24.	Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011 PMCID:PMC2975863 PMID:20728450
25.	Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920 PMCID:PMC2913227 PMID:20360254
26.	DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328
27.	DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008 PMCID:PMC2442827 PMID:18423486
28.	Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06 PMCID:PMC1800730 PMID:17145769
29.	DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200 PMCID:PMC2724003 PMID:16950770
30.	DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231 PMID:16636172
31.	Muslin AJ, DeBosch B. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809
32.	DeBosch BJ, Deo BK, Kumagai AK. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632
33.	DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881
34.	Michael P. Franczyk, Nathan Qi, Kelly L. Stromsdorfer, Chengcheng Li, Shintaro Yamaguchi1, Hiroshi Itoh, Mihoko Yoshino, Brian N. Finck, Brian J. DeBosch, Samuel Klein, Jun Yoshino. Importance of adipose tissue NAD+ biology in regulating metabolic flexibility Endocrinology.