Indi Trehan, MD, MPH, DTM&H  itrehan@wustl.edu

Emergency Medicine

phone: (314) 454-2341

Research Interests

My overall research interest is in the improvement of global child health. Thematically, my primary foci within this exceedingly broad area are: * the development of a better understanding of the pathophysiology underlying chronic and acute childhood malnutrition* improving the diagnosis and treatment of malnourished children* understanding and breaking the vicious malnutrition-infection cycle that is responsible for ~45% of all childhood deaths worldwide To this end, I am part of a multidisciplinary team at Washington University in St. Louis led by Professor Mark Manary. We are actively conducting a number of clinical and translational studies addressing these themes at a number of clinical research sites in Malawi and with laboratory-based collaborators domestically, focusing on improving the care of malnourished children and pregnant women, as well as delving deeply into the pathophysiology, diagnosis, and amelioration of environmental enteric dysfunction. I am also challenged by my patients to improve health care in the developing world, particularly research into the adaptation and application of rich-world medical care to children in underserved settings. My specific interests in this domain are in the use of bedside ultrasound, rapid diagnostic tests, and technologies for respiratory support.

Education

  • BS, Chancellor's Scholar, University of California, Berkeley1998
  • MD, Northwestern University2004
  • MPH, Northwestern University2004
  • DTM&H, Universidad Peruana Cayetano Heredia and Gorgas Memorial Institute of Tropical & Preventive Medicine2006

Training

  • Research Fellowship, Howard Hughes Medical Institute2000 - 2002
  • Pediatrics Residency, Cincinnati Children's Hospital Medical Center2004 - 2007
  • Pediatric Emergency Medicine Fellowship, Washington University in St. Louis2007 - 2013
  • Pediatric Infectious Diseases Fellowship, Washington University in St. Louis2007 - 2013
  • Clinical Ultrasound in Tropical Infectious Diseases Course, Universidad Peruana Cayetano Heredia and Georgia Regents University2012
  • Pediatric Emergency Medicine and Critical Care Medicine Bedside Ultrasound Course, The Children's Hospital of Philadelphia2013
  • McMaster Evidence-Based Clinical Practice Teaching Workshop, McMaster University2016

Licensure and Board Certification

  • Certificate of Knowledge in Clinical Tropical Medicine and Traveler's Health, American Society of Tropical Medicine and Hygiene 2006
  • Diplomate, National Board of Medical Examiners 2007
  • Certificate of Knowledge in Travel Medicine, International Society of Travel Medicine 2007
  • MO, Physician and Surgeon License 2008
  • Diplomate in General Pediatrics, American Board of Pediatrics 2008
  • General Physician License, Medical Council of Malawi 2011
  • Advanced Trauma Life Support 2013
  • Diplomate in Pediatric Infectious Diseases, American Board of Pediatrics 2013
  • Pediatric Advanced Life Support 2014

Honors

  • Chancellor's Scholarship, University of California, Berkeley1994 - 1998
  • Medical Student Research Training Fellowship, Howard Hughes Medical Institute2000 - 2004
  • Benzing / Lowe Award for Excellence in Critical Care, Cincinnati Children's Hospital Medical Center2007
  • Samuel Dalinsky Memorial Award for the Outstanding Graduating Pediatric Resident, Cincinnati Children's Hospital Medical Center2007
  • Outstanding Fellow Teaching Award, Washington University in St. Louis Pediatrics Residency Program2007 - 2008
  • Ruth L. Kirschstein National Research Service Award T32-HD049338, National Institute of Child Health and Human Development2009 - 2011
  • Pediatric Loan Repayment Program Award L40-HD066655, National Institute of Child Health and Human Development2010 - 2012
  • Best Fellow Abstract at 2011 Pediatric Academic Societies’ Annual Meeting, Academic Pediatric Association2011
  • Outstanding Lecturer of the Month for December 2012, Washington University in St. Louis Pediatrics Residency Program2012
  • Best Poster by a Postdoctoral Fellow at 2013 Center for Global Health and Infectious Disease Conference, Washington University in St. Louis Center for Global Health and Infectious Disease2013
  • Pediatric Clinical Educator Award, Washington University in St. Louis Emergency Medicine Residency Program2013 - 2014
  • Councilor, American Society for Tropical Medicine and Hygiene Committee on Global Health2013 - 2015
  • Outstanding Lecturer of the Month for December 2013, Washington University in St. Louis Children's Pediatrics Residency Program2013
  • Outstanding Subspecialty Teacher Award, Washington University in St. Louis Pediatrics Residency Program2014 - 2015
  • Keynote Speaker, Northwestern University Program in Public Health MD/MPH Graduation2015
  • Outstanding Commitment to Teaching Award, Washington University in St. Louis Pediatrics Residency Program2015 - 2016
  • Faculty Inductee, Gold Humanism Honor Society, Washington University in St. Louis School of Medicine2016
  • Humanism in Medicine Award, Washington University in St. Louis School of Medicine2016

Selected Publications view all (64)


Publication Co-Authors

1.
Environmental enteric dysfunction is associated with altered bile acid metabolism. J Pediatr Gastroneterol Nutr. 2017;64(4):536-540. doi:10.1097/MPG.0000000000001313  PMCID:PMC5164860  PMID:27322559 
2.
Environmental enteric dysfunction is associated with poor linear growth and can be identified by host fecal mRNAs. J Pediatr Gastroenterol Nutr. 2016;63(5):453-459. doi:10.1097/MPG.0000000000001315  PMCID:PMC5084633  PMID:27347722 
3.
Global emergency medicine: a review of the literature from 2015. Acad Emerg Med. 2016;23(10). doi:10.1111/acem.12999  PMID:27146277 
4.
Perspective: the potential role of essential amino acids and the mechanistic target of rapamycin complex 1 (mTORC1) pathway in the pathogenesis of child stunting. Adv Nutr. 2016;7(5):853-865. doi:10.3945/an.116.013276  PMCID:PMC5015042  PMID:27633102 
5.
New insights into environmental enteric dysfunction. Arch Dis Child. 2016;101(8):741-744. doi:10.1136/archdischild-2015-309534  PMID:26933151 
6.
Amoxicillin for severe acute malnutrition in children. N Engl J Med. 2016;375(2):191. doi:10.1056/NEJMc1605388  PMID:27410940 
7.
An important chapter in the infection-malnutrition story. Lancet Glob Health. 2016;4:e430-e431. doi:10.1016/S2214-109X(16)30110-3  PMID:27289200 
8.
The association of serum choline with linear growth failure in young children from rural Malawi. Am J Clin Nutr. 2016;104(7):191-197. doi:10.3945/ajcn.115.129684  PMCID:PMC4919529  PMID:27281303 
9.
Metabolic alterations in children with environmental enteric dysfunction. Sci Rep. 2016;6:28009. doi:10.1038/srep28009  PMCID:PMC4904796  PMID:27294788 
10.
Child stunting is associated with low circulating essential amino acids. EBioMedicine. 2016;6:246-252. doi:10.1016/j.ebiom.2016.02.030  PMCID:PMC4856740  PMID:27211567