My overall research interest is in the improvement of global child health. Thematically, my primary foci within this exceedingly broad area are: * the development of a better understanding of the pathophysiology underlying chronic and acute childhood malnutrition* improving the diagnosis and treatment of malnourished children* understanding and breaking the vicious malnutrition-infection cycle that is responsible for ~45% of all childhood deaths worldwide To this end, I am part of a multidisciplinary team at Washington University in St. Louis led by Professor Mark Manary. We are actively conducting a number of clinical and translational studies addressing these themes at a number of clinical research sites in Malawi and with laboratory-based collaborators domestically, focusing on improving the care of malnourished children and pregnant women, as well as delving deeply into the pathophysiology, diagnosis, and amelioration of environmental enteric dysfunction. I am also challenged by my patients to improve health care in the developing world, particularly research into the adaptation and application of rich-world medical care to children in underserved settings. My specific interests in this domain are in the use of bedside ultrasound, rapid diagnostic tests, and technologies for respiratory support.