Zachary A. Vesoulis, M.D.  vesoulis_z@kids.wustl.edu

Instructor in Pediatrics, Newborn Medicine
Researcher, Patient Oriented Research Unit
Patient Oriented Research UnitNewborn Medicine

phone: (314) 454-6148

Research Interests

I am interested in understanding the interaction between the brain and the cardiovascular system, in both preterm and term infants, and how disruption of this connection contributes to the most common forms of neonatal brain injury including intraventricular hemorrhage, white matter injury, hypoxic-ischemic injury, and seizures. In particular, the work in our research lab focuses on the relationship between systemic perfusion and autoregulatory control of cerebral blood flow. We utilize high-resolution multi-modality physiology measurements (ECG, arterial blood pressure, NIRS, pulse oximetry, EEG/aEEG) in conjunction with signal processing algorithms to build a model of this interaction and better understand the mechanisms of control.

The goal of this work is to understand the factors that contribute to the pathogenesis of brain injury in neonates, provide a more informed prognosis to families, and ultimately, to develop new neuroprotective strategies to prevent brain injury altogether.

Education

  • BA, Miami University2005
  • MD, The Ohio State University2009

Training

  • Internship, St. Louis Children's Hospital2009 - 2010
  • Residency, St. Louis Children's Hospital2010 - 2011
  • Fellowship, Washington University School of Medicine2011 - 2014

Licensure and Board Certification

  • Advanced Cardiac Life Support 2009
  • Basic Life Support 2009
  • Pediatric Advanced Life Support 2009
  • Neonatal Resuscitation Program 2009
  • Advanced Trauma Life Support 2013
  • MO, Medical License 2014
  • American Board of Pediatrics, General Pediatrics 2014
  • American Board of Pediatrics, Neonatal-Perinatal Medicine 2016

Honors

  • Miami University Scholar-Leader Award2003
  • Alspaugh Award for Professionalism in the Field of Medicine2005 - 2009
  • James P. Keating Outstanding Resident Award2011
  • PAS Young Investigator's Travel Award2014
  • Outstanding Fellow Teaching Award2014
  • Travel Award, Burroughs Wellcome Fund2016
  • Outstanding Citizenship Award, Clinical Research Training Center2016
  • Early Career Investigator Highlight - Pediatric Research2017

Selected Publications view all (24)


Publication Co-Authors

1.
Gestational age-dependent relationship between cerebral oxygen extraction and blood pressure. Pediatr Res. 2017;82(6):934-939. PMCID:PMC5685915  PMID:28902182 
2.
Early hyperoxia burden detected by cerebral near-infrared spectroscopy is superior to pulse oximetry for prediction of severe retinopathy of prematurity. J Perinatol. 2016;36(11):966-971. PMCID:PMC5079836  PMID:27559717 
3.
Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555 
4.
A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. doi:10.1038/pr.2015.238  PMCID:PMC4821724  PMID:26571222 
5.
Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515 
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