Zachary A. Vesoulis, M.D.

Instructor in Pediatrics, Newborn Medicine
Patient Oriented Research UnitNewborn Medicine

phone: (314)-286-1524

Research Interests

I am interested in understanding the interaction between the brain and the cardiovascular system in both preterm and term infants and how disruption of this connection contributes to the most common forms of neonatal brain injury including intraventricular hemorrhage, white matter injury, HIE, and seizures. In particular, the work in our research lab focuses on the relationship between systemic perfusion and autoregulatory control of cerebral blood flow. We utilize high-resolution multi-modality physiology measurements (ECG, arterial blood pressure, NIRS, pulse oximetry, EEG/aEEG) in conjunction with signal processing algorithms to build a model of this interaction.

The goal of this work is to understand the factors that contribute to the pathogenesis of brain injury in neonates, provide more a more informed prognosis to families, and ultimately, to develop new neuroprotective strategies to prevent brain injury altogether.


  • B.A., Miami University2005
  • M.D., The Ohio State University2009


  • Internship, St. Louis Children's Hospital2009 - 2010
  • Residency, St. Louis Children's Hospital2010 - 2011
  • Fellowship, Washington University School of Medicine2011 - 2014

Licensure and Board Certification

  • Advanced Cardiac Life Support2009
  • Basic Life Support2009
  • Pediatric Advanced Life Support2009
  • Neonatal Resuscitation Program2009
  • Advanced Trauma Life Support2013
  • MO, Medical License2014
  • American Board of Pediatrics, General Pediatrics2014
  • American Board of Pediatrics, Neonatal-Perinatal Medicine2016


  • Miami University Scholar-Leader Award2003
  • Alspaugh Award for Professionalism in the Field of Medicine2005 - 2009
  • James P. Keating Outstanding Resident Award2011
  • PAS Young Investigator's Travel Award2014
  • Outstanding Fellow Teaching Award2014
  • Travel Award, Burroughs Wellcome Fund2016
  • Outstanding Citizenship Award, Clinical Research Training Center2016

Selected Publications view all (13)

Publication Co-Authors

  1. Vesoulis ZA, McPherson C, Neil JJ, Mathur AM, Inder TE. Early High-Dose Caffeine Increases Seizure Burden in Extremely Preterm Neonates: A Preliminary Study. J Caffeine Res. 2016;6(3):101-107. PMCID:PMC5031091  PMID:27679737  
  2. Vesoulis ZA, El Ters NM, Wallendorf M, Mathur AM. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2016;36(4):291-5. doi:10.1038/jp.2015.185  PMCID:PMC4808440  PMID:26633144  
  3. Vesoulis ZA, Liao SM, Trivedi SB, Ters NE, Mathur AM. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. doi:10.1038/pr.2015.238  PMCID:PMC4821724  PMID:26571222  
  4. Vesoulis ZA, Ters NE, Foster A, Trivedi SB, Liao SM, Mathur AM. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555  
  5. Vesoulis ZA, Paul RA, Mitchell TJ, Wong C, Inder TE, Mathur AM. Normative amplitude-integrated EEG measures in preterm infants. J Perinatol. 2015;35(6):428-33. doi:10.1038/jp.2014.225  PMCID:PMC4447544  PMID:25521561  
  6. Vesoulis ZA, Attarian SJ, Zeller B, Cole FS. Minoxidil-associated anorexia in an infant with refractory hypertension. Pharmacotherapy. 2014;34(12):e341-4. doi:10.1002/phar.1495  PMID:25280267  
  7. Vesoulis ZA, Galindo R, Ornstein BW, White AJ. Neuro-Behçets in a Child Child Neurology Open. 2014;1(1). doi:10.1177/2329048X14550505   
  8. Vesoulis ZA, Mathur AM. Advances in management of neonatal seizures. Indian J Pediatr. 2014;81(6):592-8. doi:10.1007/s12098-014-1457-9  PMCID:PMC4338003  PMID:24796413  
  9. Vesoulis ZA, Inder TE, Woodward LJ, Buse B, Vavasseur C, Mathur AM. Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515  
  10. Vesoulis ZA, Vachharajani AJ. Index of Suspicion in the Nursery Case 2: Late Preterm Infant With a Difficult Intubation Neoreviews. 2014;15(15):e99-e103. doi:10.1542/neo.15-3-e99  
  11. Vesoulis ZA, Lust CE, Liao SM, Trivedi SB, Mathur AM. Early hyperoxia burden detected by cerebral near-infrared spectroscopy is superior to pulse oximetry for prediction of severe retinopathy of prematurity. J Perinatol. 2016;36(11):966-971. PMCID:PMC5079836  PMID:27559717  
  12. Leadbetter KZ, Vesoulis ZA, White FV, Schmidt RE, Khanna G, Shimony JS, Mathur AM. The role of post-mortem MRI in the neonatal intensive care unit. J Perinatol. 2016. PMID:27654494  
  13. Rao R, Trivedi S, Vesoulis Z, Liao SM, Smyser CD, Mathur AM. Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy. J Pediatr. 2016. PMID:27979578