Pediatric Research

Lori R. Holtz, M.D., M.S.P.H. loriholtz@wustl.edu

Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition

View my lab

Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Education

BS, Tulane University, 1999
MD, The Ohio State University College of Medicine, 2003
MSPH, St. Louis University School of Public Health, 2014

Training

Residency, Vanderbilt Children's Hospital, 2003 - 2006
Fellowship, Washington University, 2006 - 2009

Licensure and Board Certification

2006 - 2026American Board of Pediatrics
2008 - PresMO
2009 - 2023American Board of Pediatrics, Sub-board of Pediatric Gastroenterology

Honors and Awards

National Science Scholar, 1995
Tulane University Partial Academic Scholarship, 1995 - 1999
Funding from the National Science Foundation research experience for undergraduates, 1998
Cum Laude, Tulane University, 1999
NASPGHAN travel grant, 2008
Children's Discovery Institute Faculty Scholar, 2013 - 2018
St. Louis Best Doctors, 2015 - 2020
Washington University Institute for Public Health Scholar, 2016 - Pres
March of Dimes Basil O'Connor Award, 2017 - 2020
Doris Duke Clinical Scientist Development Award, 2017 - 2021

Selected Publications view all (32)

Publication Co-Authors

Gregory A. Storch, M.D.

Shalini Shenoy, M.D.

Stuart C. Sweet, M.D., Ph.D.

Phillip I. Tarr, M.D.

S. Paul Hmiel, M.D., Ph.D.

Kristine Wylie, Ph.D.

Mark J. Manary, M.D.

Patrick Sloan

Barbara B. Warner, M.D., MSc

Charles Canter, M.D.

Andrew B. Janowski MD

Guoyan Zhao

1.	Desai C, Handley SA, Rodgers R, Rodriguez C, Ordiz MI, Manary MJ, Holtz LR. Growth velocity in children with Environmental Enteric Dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children. PLoS Negl Trop Dis. 2020;14(6):e0008387. PMID:32574158
2.	Sloan P, Rodriguez C, Bedell BA, Murray J, Dagle J, Ryckman K, Holtz L. Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort. J Matern Fetal Neonatal Med. 2020;1-7. PMID:32401076
3.	Maqsood R, Rodgers R, Rodriguez C, Handley SA, Ndao IM, Tarr PI, Warner BB, Lim ES, Holtz LR. Discordant transmission of bacteria and viruses from mothers to babies at birth. Microbiome. 2019;7(1):156. PMID:31823811
4.	Lim ES, Rodriguez C, Holtz LR. Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome. 2018;6(1):87. PMCID:PMC5946436 PMID:29751830
5.	Xaverius P, Alman C, Holtz L, Yarber L. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. PMID:26537389
6.	Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015;21(10):1228-34. PMCID:PMC4710368 PMID:26366711
7.	Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. PMCID:PMC4465002 PMID:25975198
8.	Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. PMCID:PMC4254309 PMID:25262473
9.	Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. PMCID:PMC4054231 PMID:24789796
10.	Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. PMCID:PMC4096378 PMID:24725928
11.	Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. PMCID:PMC3545029 PMID:23084422
12.	Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. PMCID:PMC3471627 PMID:23017293

1.	Sloan PE, Rodriguez C, Holtz LR. Viral prevalence by gestational age and season in a large neonatal cord blood cohort. J Matern Fetal Neonatal Med. 2021;1-6. PMID:34587860
2.	Sakhuja S, Holtz LR. Progression of pediatric celiac disease from potential celiac disease to celiac disease: a retrospective cohort study. BMC Pediatr. 2021;21(1):149. PMID:33781221
3.	Desai C, Handley SA, Rodgers R, Rodriguez C, Ordiz MI, Manary MJ, Holtz LR. Growth velocity in children with Environmental Enteric Dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children. PLoS Negl Trop Dis. 2020;14(6):e0008387. PMID:32574158
4.	Sloan P, Rodriguez C, Bedell BA, Murray J, Dagle J, Ryckman K, Holtz L. Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort. J Matern Fetal Neonatal Med. 2020;1-7. PMID:32401076
5.	Wang L, de Ángel Solá D, Acevedo Flores M, Schriefer A, Wang L, Gerónimo López K, Chang A, Warner B, Shan L, Holtz LR, Rosario Matos N. Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut. Pediatr Res. 2020. PMID:32172280
6.	Liu TC, VanBuskirk K, Ali SA, Kelly MP, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore S, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis. 2020;14(1):e0007975. PMID:31929525
7.	Maqsood R, Rodgers R, Rodriguez C, Handley SA, Ndao IM, Tarr PI, Warner BB, Lim ES, Holtz LR. Discordant transmission of bacteria and viruses from mothers to babies at birth. Microbiome. 2019;7(1):156. PMID:31823811
8.	Lim ES, Rodriguez C, Holtz LR. Reply Re: "Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community". Microbiome. 2019;7(1):21. PMCID:PMC6373012 PMID:30755269
9.	Lim ES, Rodriguez C, Holtz LR. Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome. 2018;6(1):87. PMCID:PMC5946436 PMID:29751830
10.	Melamed R, Storch GA, Holtz LR, Klein EJ, Herrin B, Tarr PI, Denno DM. Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea. J Pediatric Infect Dis Soc. 2017;6(3):e49-e54. PMID:28186546
11.	Janowski AB, Bauer IK, Holtz LR, Wang D. Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol. 2017. PMCID:PMC5599743 PMID:28701405
12.	Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMCID:PMC5515247 PMID:28152382
13.	Xaverius P, Alman C, Holtz L, Yarber L. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. PMID:26537389
14.	Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2015;1(1):vev017. PMCID:PMC5014484 PMID:27774288
15.	Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015;21(10):1228-34. PMCID:PMC4710368 PMID:26366711
16.	Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. PMCID:PMC4465002 PMID:25975198
17.	Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. PMCID:PMC4254309 PMID:25262473
18.	Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. PMCID:PMC4054231 PMID:24789796
19.	Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. PMCID:PMC4096378 PMID:24725928
20.	Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. PMCID:PMC3545029 PMID:23084422
21.	Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. PMCID:PMC3471627 PMID:23017293
22.	Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D. Novel astroviruses in children, Egypt. Emerg Infect Dis. 2011;17(12):2391-3. PMCID:PMC3311207 PMID:22172277
23.	Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D. Astrovirus MLB2 viremia in febrile child. Emerg Infect Dis. 2011;17(11):2050-2. PMCID:PMC3310569 PMID:22099095
24.	Holtz LR, Bauer IK, Rajendran P, Kang G, Wang D. Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children. PLoS One. 2011;6(12):e28647. PMCID:PMC3235140 PMID:22174853
25.	Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010;17(10):1584-8. PMCID:PMC2952992 PMID:20739504
26.	Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009;83(24):13019-25. PMCID:PMC2786824 PMID:19812170
27.	Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009;6:161. PMCID:PMC2765957 PMID:19814825
28.	Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009;6:86. PMCID:PMC2706813 PMID:19552824
29.	Holtz LR, Neill MA, Tarr PI. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136(6):1887-98. PMID:19457417
30.	Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D. Detection of newly described astrovirus MLB1 in stool samples from children. Emerg Infect Dis. 2009;15(3):441-4. PMCID:PMC2666294 PMID:19239759
31.	Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J. 2008;5:159. PMCID:PMC2615758 PMID:19102772
32.	Voss TC, Goldman LR, Seek SL, Miller TL, Mayo KE, Somogyvari-Vigh A, Arimura A, Hurley DL. GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Mol Cell Endocrinol. 2001;172(1-2):125-34. PMID:11165046