Amjad Horani, M.D.  horani_a@wustl.edu

Assistant Professor of Pediatrics, Allergy, Immunology and Pulmonary Medicine
Allergy, Immunology and Pulmonary MedicinePathobiology

phone: 314 454 2158

Research Interests

Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.

Education

  • BSc, with distinction, The Hebrew University of Jerusalem1999
  • MD, The Hebrew University of Jerusalem2004

Training

  • Pediatric Residency, Hadassah-Hebrew University Medical Center2004 - 2009
  • Fellowship in Pulmonary Medicine, St. Louis Children's Hospital2010 - 2013
  • Advanced fellowship in Pediatric Pulmonary Medicine, St. Louis Children's Hospital2013 - 2014

Licensure and Board Certification

  • Israeli Medical License 2004
  • Israeli Board of Pediatrics 2009
  • MO, Missouri Medical License 2014
  • Israeli Board of Pediatric Pulmonary Medicine 2015

Honors

  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2005
  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2006
  • Dr. BOYKES Honorary award for excellent Pediatric Research, Israeli Association of Clinical Pediatrics2007
  • Young Clinician Award, Hadassah-Hebrew University Medical Center2008
  • Dr. DIMSON Honorary Faculty award for excellent Pediatric Research, The Hebrew University-Hadassah Faculty of Medicine2008
  • Best fellows abstract, pediatric research retreat, Washington University in St. Louis2012
  • Martin K. and Jill F. Sneider Endowed Fellowship Award2013
  • Annual ATS Assembly on Pediatrics Scientific Award2013
  • The Japanese Respiratory Society International Session Award2014
  • Gordon conference Abstract Award2015

Selected Publications view all (27)


Publication Co-Authors

1.
Primary ciliary dyskinesia and associated sensory ciliopathies. Expert Rev Respir Med. 2016;10(5):569-76. doi:10.1586/17476348.2016.1165612  PMCID:PMC4893162  PMID:26967669 
2.
Genetics and biology of primary ciliary dyskinesia. Paediatr Respir Rev. 2015. doi:10.1016/j.prrv.2015.09.001  PMID:26476603 
3.
Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res. 2014;75(1-2):158-64. doi:10.1038/pr.2013.200  PMCID:PMC3946436  PMID:24192704 
4.
NKp46 regulates allergic responses. Eur J Immunol. 2013;43(11):3006-16. doi:10.1002/eji.201343388  PMCID:PMC3867659  PMID:23878025 
5.
Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol. 2013;49(3):341-7. doi:10.1165/rcmb.2013-0046TE  PMCID:PMC3824057  PMID:23713995 
6.
CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia. PLoS One. 2013;8(8):e72299. doi:10.1371/journal.pone.0072299  PMCID:PMC3753302  PMID:23991085 
7.
Applications of mouse airway epithelial cell culture for asthma research. Methods Mol Biol. 2013;1032:91-107. doi:10.1007/978-1-62703-496-8_7  PMID:23943446 
8.
LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One. 2013;8(3):e59436. doi:10.1371/journal.pone.0059436  PMCID:PMC3602302  PMID:23527195 
9.
Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91(4):685-93. doi:10.1016/j.ajhg.2012.08.022  PMCID:PMC3484505  PMID:23040496 
10.
Triphala (PADMA) extract alleviates bronchial hyperreactivity in a mouse model through liver and spleen immune modulation and increased anti-oxidative effects. Ther Adv Respir Dis. 2012;6(4):199-210. doi:10.1177/1753465812452194  PMID:22763675