Jeffrey Magee, M.D., Ph.D.  Magee_J@kids.wustl.edu

Assistant Professor, Division of Hematology-Oncology, Department of Pediatrics
Developmental BiologyHematology and Oncology

phone: 314-286-0032

Research Interests

The Magee lab studies the differences between childhood and adult leukemia. Our goal is to understand why children get leukemia when they are not subject to the effects of aging, environmental exposures and inflammation that can contribute to malignancies in adults. We are using mice to model the effects of different infant and adult leukemia-causing mutations at different ages. We have discovered that mutations have different effects on gene expression, and ultimately cell fate, at different stages of life. We are now working to decode the interactions between mechanisms that regulate development of the blood system and the mutations that cause leukemia. These studies will ultimately lead to new treatments for childhood and adult leukemia.

Education

  • BS, University of Wisconsin1997
  • MD, Washington University, School of Medicine2005
  • PhD, Washington University, School of Medicine2005

Training

  • Residency, University of Michigan Hospitals and Health Centers2005 - 2007
  • Fellowship, University of Michigan Hospitals and Health Centers2007 - 2010

Licensure and Board Certification

  • Pediatric Advanced Life Support
  • General Pediatrics, # 95246 2009
  • MI, Michigan Medical Board 2009
  • Pediatric Hematology/Oncology, # 2409 2011
  • TX, Texas Medical Board 2011
  • MO, Missouri Board of Registration for the Healing Arts 2013

Honors

  • Hilldale Undergraduate/Faculty Research Fellowship, University of Wisconsin-Madison1995
  • Barry M. Goldwater Scholarship, University of Wisconsin-Madison1996
  • Howard Hughes Medical Institute Fellowship, University of Wisconsin-Madison1996
  • I. Jerome Flance Medical Science Traineeship, Washington University School of Medicine1999
  • American College of Physicians Award for Excellence in Physical Diagnosis, Washington University School of Medicine2000
  • Outstanding Teaching Assistant, Washington University School of Medicine2000
  • David M. Kipnis Thesis Award, Washington University School of Medicine2005
  • Spencer T. and Ann W. Olin Medical Science Fellowship, Washington University School of Medicine2005
  • Pediatric Scientist Development Program Fellowship, University of Michigan Medical School2008
  • Laurence Carolin Award, University of Michigan Medical School2010
  • UT-Southwestern Disease Oriented Clinical Scholar Fellowship (declined)2013
  • Children's Discovery Institute Faculty Scholar2014
  • Hyundai Hope Scholar2014
  • St. Baldrick's Scholar Award2014
  • Gabrielle's Angel Medical Research Award2016
  • V Foundation Scholar Award2016
  • Alex's Lemonade Stand Foundation 'A' Award2016
  • American Society of Hematology Junior Faculty Scholar Award2016

Selected Publications view all (18)


Publication Co-Authors

1.
Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines Stem Cell Reports. 2016;6(6):806-814. PMID:27185281 
2.
Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia. 2015;29(1):255-8. doi:10.1038/leu.2014.278  PMID:25234167 
3.
Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014;509(7498):49-54. doi:10.1038/nature13035  PMCID:PMC4015626  PMID:24670665 
4.
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012;11(3):415-28. doi:10.1016/j.stem.2012.05.026  PMCID:PMC3447536  PMID:22958933 
5.
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283-96. doi:10.1016/j.ccr.2012.03.003  PMID:22439924