Pediatric Research

Laura Schuettpelz, M.D, Ph.D. schuettpelz_l@kids.wustl.edu

Assistant Professor of Pediatrics, Hematology and Oncology

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Department of Medicine Hematology and Oncology

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Education

BS, Summa Cum Laude, Creighton University, 1995
PhD, Northwestern University, 2000
MD, Northwestern University, 2005

Training

Residency in Pediatrics, Washington Univeristy School of Medicine, 2005 - 2008
Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine, 2008 - 2011

Licensure and Board Certification

2005 - PresMO, Missouri Medical License
2009 - 2019General Pediatrics
2013 - 2023Pediatric Hematology/Oncology

Honors and Awards

David Gilstrap Award, 2008
James P.Keating Oustanding Resident Award, 2008
Outstanding Fellow Teaching Award, 2009
Scholar of the Child Health Research Center of Excellence in Developmental Biology, 2012 - Pres
Faculty Scholar Award, Children's Discovery Institute of Washington University, 2013 - Pres

Selected Publications view all (22)

Publication Co-Authors

Todd Druley, M.D., Ph.D.

Matthew I. Goldsmith, M.D.

Mary C. Dinauer, M.D., Ph.D.

Jeffrey Magee, M.D., Ph.D.

Sima Bhatt

Andrew Cluster

David B. Wilson, M.D., Ph.D.

Dorothy Katherine Grange, M.D.

Isaiah turnbull

Manish Aggarwal

R. Mark Grady, M.D.

1.	Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 2014;28(9):1851-60. doi:10.1038/leu.2014.68 PMCID:PMC4130805 PMID:24518205
2.	Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227-30. doi:10.1038/nature11926 PMCID:PMC3600148 PMID:23434756
3.	Schuettpelz LG, Link DC. Regulation of hematopoietic stem cell activity by inflammation. Front Immunol. 2013;4:204. doi:10.3389/fimmu.2013.00204 PMCID:PMC3715736 PMID:23882270
4.	Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012;120(15):2981-9. doi:10.1182/blood-2012-02-409839 PMCID:PMC3471512 PMID:22936656
5.	Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA. 2011;305(15):1568-76. doi:10.1001/jama.2011.473 PMCID:PMC3170052 PMID:21505135
6.	Schuettpelz LG, Link DC. Niche competition and cancer metastasis to bone. J Clin Invest. 2011;121(4):1253-5. doi:10.1172/JCI57229 PMCID:PMC3069798 PMID:21436576
7.	Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193 PMID:19621452
8.	Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2 PMID:19829151
9.	Meng Y, Graves L, Do TV, So J, Fishman DA. Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes. Gynecol Oncol. 2004;95(3):488-95. doi:10.1016/j.ygyno.2004.07.052 PMID:15581951
10.	Graves LE, Ariztia EV, Navari JR, Matzel HJ, Stack MS, Fishman DA. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res. 2004;64(19):7045-9. doi:10.1158/0008-5472.CAN-04-1800 PMID:15466198

1.	Fuchs A, Monlish DA, Ghosh S, Chang SW, Bochicchio GV, Schuettpelz LG, Turnbull IR. Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF. J Immunol. 2019;202(10):3020-3032. PMCID:PMC6504560 PMID:30988118
2.	Aggarwal M, Schuettpelz L, Kolodziej J, Grady RM. Rapid development of pulmonary hypertension during treatment of paediatric cancer. Cardiol Young. 2019;29(3):286-289. doi:10.1017/S1047951118002196 PMID:30678742
3.	Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018. PMID:29618478
4.	Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG. Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS. Blood. 2018. PMID:29358180
5.	Trompouki E, Mullen L, Fernandez-Reyes D, Yodoi J, Kim S, Schuettpelz LG. Editorial: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy. Front Immunol. 2017;8:660. PMCID:PMC5454062 PMID:28626462
6.	Karpova D, Ritchey J, Holt M, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig M, Boenig H, DiPersio JF. Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells. Blood. 2017. PMID:28400375
7.	Monlish DA, Bhatt ST, Schuettpelz LG. The Role of Toll-Like Receptors in Hematopoietic Malignancies. Front Immunol. 2016;7:390. PMCID:PMC5039188 PMID:27733853
8.	Herman AC, Monlish DA, Romine MP, Bhatt ST, Zippel S, Schuettpelz LG. Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms. Blood Cancer J. 2016;6:e437. PMID:27315114
9.	Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016;6(6):806-14. PMCID:PMC4911494 PMID:27185281
10.	Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 2014;28(9):1851-60. doi:10.1038/leu.2014.68 PMCID:PMC4130805 PMID:24518205
11.	Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227-30. doi:10.1038/nature11926 PMCID:PMC3600148 PMID:23434756
12.	Schuettpelz LG, Link DC. Regulation of hematopoietic stem cell activity by inflammation. Front Immunol. 2013;4:204. doi:10.3389/fimmu.2013.00204 PMCID:PMC3715736 PMID:23882270
13.	Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012;120(15):2981-9. doi:10.1182/blood-2012-02-409839 PMCID:PMC3471512 PMID:22936656
14.	Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA. 2011;305(15):1568-76. doi:10.1001/jama.2011.473 PMCID:PMC3170052 PMID:21505135
15.	Schuettpelz LG, Link DC. Niche competition and cancer metastasis to bone. J Clin Invest. 2011;121(4):1253-5. doi:10.1172/JCI57229 PMCID:PMC3069798 PMID:21436576
16.	Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193 PMID:19621452
17.	Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2 PMID:19829151
18.	Meng Y, Graves L, Do TV, So J, Fishman DA. Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes. Gynecol Oncol. 2004;95(3):488-95. doi:10.1016/j.ygyno.2004.07.052 PMID:15581951
19.	Graves LE, Ariztia EV, Navari JR, Matzel HJ, Stack MS, Fishman DA. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res. 2004;64(19):7045-9. doi:10.1158/0008-5472.CAN-04-1800 PMID:15466198
20.	Segal SP, Graves LE, Verheyden J, Goodwin EB. RNA-Regulated TRA-1 nuclear export controls sexual fate. Dev Cell. 2001;1(4):539-51. PMID:11703944
21.	Graves LE, Segal S, Goodwin EB. TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. Nature. 1999;399(6738):802-5. doi:10.1038/21682 PMID:10391248
22.	Jan E, Motzny CK, Graves LE, Goodwin EB. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J. 1999;18(1):258-69. doi:10.1093/emboj/18.1.258 PMCID:PMC1171120 PMID:9878068