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Publications

Selected Publications

  1. Song H, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 2009; 69: 879-886. [ pubmed ]

  2. Liu C-C, Pearson C, Bu G. Cooperative folding and ligand-binding properties of LRP6 beta- propeller domains. J. Biol. Chem. 2009; 284: 15299-15307. [ pubmed ]

  3. Cirrito JR, Kang J-E, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-B in vivo. Neuron. 2008; 58: 42-51. [ pubmed ]

  4. Lee J, Retamal C, Cuitino L, Caruano-Yzermans A, Shin J-E, van Kerkhof P, Marzolo M-P, Bu G. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J. Biol. Chem. 2008; 283: 11501-11508. [ pubmed ]

  5. Liu Q, Zerbinatti CV, Zhang J, Hoe H-S, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 2007; 56:66-78. [ pubmed ]

  6. Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul S, Holtzman DM, Bu G: Effects of LRP and apoE on intraneuronal Abeta in PDAPP mice. J Biol Chem 2006; 281:36180-36186. [ pubmed ]

  7. Van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G: Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J 2005, 24:2851-2861. [ pubmed ]

Selected Reviews

  1. Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 2009; 10: 333-344. [ pubmed ]

  2. Kanekiyo T, Bu G. LRP1 and cerebral amyloid angiopathy. Future Neurology. 2009; 4: 55-65. [  Future Neurology ]

  3. Marzolo M-P, Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Semin Cell Dev. Biol. 2008; 20: 191-200. [ pubmed ]

     

 

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