Megan is a Pediatric Rheumatologist and Immunologist, and Director of Clinical Immunology. The laboratory is focused on mechanisms of immune cell control, including regulation of natural killer cell activation and mechanisms driving pediatric immune-mediated disease.
Natural killer (NK) cells are innate immune lymphocytes that produce cytokines and can kill target cells. They are important for the early control of viral infection and also play a role in tumor immunosurveillance. Current work in the laboratory is focused on understanding how metabolic pathways regulate NK cell functional responses. The second focus of our laboratory is on the origins of pediatric immune dysregulation. We use genomic sequencing to identify genetic causes of pediatric disease and work to better understand these diseases using in vitro and in vivo models.
Work in our laboratory is supported by the National Institutes of Health, The Children's Discovery Institute, the Jeffrey Modell Foundation, the Immune Deficiency Foundation, the Crohn’s and Colitis Foundation, and the St. Louis Children’s Hospital Foundation.