Hello, and welcome to the DeBosch Lab! We study hepatic and enterocyte determinants of metabolic syndrome and non-alcoholic fatty liver disease.


  • Cassie Higgins' manuscript, "Hepatic ALOXE3 is induced during the murine adaptive fasting response, and enhances insulin sensitivity by activating hepatic PPAR-gamma" is in press at the Journal of Clinical Investigation Insight!
  • Allyson Mayer was awarded the 2018 Jakschik Award for outstanding thesis work in metabolism!
  • The DeBosch Lab was just awarded a renewal on its Diabetes Research Center Grant to continue studying molecular physiological mechanisms of trehalose-induced thermogenesis!
  • Allyson's paper, Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice, has been accepted for publication in Endocrinology!
  • Paul Hruz and Brian DeBosch were named winners of the 2018 LEAP Inventors Challenge at Washington University for their invention, Selective Novel Treatment of Fatty Liver Disease
  • Yiming Zhang (Technician II) just got a paper in press at Autophagy: "Transcription Factor EB (TFEB)-dependent Induction of Thermogenesis by the Hepatocyte Solute Carrier 2A (SLC2A) inhibitor, Trehalose".
  • Allyson Mayer (DBBS Student, Developmental, Stem Cell & Regenerative Medicine) will defend her thesis in May 2018 (5 year completion time!). She completes her time in the DeBosch Lab as an Spencer and Ann Olin Fellow, and a National Science Foundation Graduate Research Fellowship Awardee.
  • Emily Feng, BS (WUSTL ArtSci 2016), DeBosch Lab Alum, enrolled at Kansas University School of Medicine
  • Oyin Adenekan (WUSTL ArtSci 2020) was awarded an HHMI undergraduate research fellowship (2018)
  • The DeBosch Lab's discoveries: Featured in Science Signaling's 2016 "Signaling Breakthroughs of the Year" (2017)
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