Lindsey Gibbons - Lab Manager

Lindsey joined the Doctor lab to study the biology of Nitric Oxide (NO) bound to red blood cells. NO plays an important role in regulating vascular tone and blood flow. She is interested in quantifying S-Nitrosothiols (S-NO) as potential Nitric Oxide donors via chemilumenescence assays and photolytic cleavage of the S-NO bond. This will aid in understanding the techniques used in measurement of NO from a variety of biological matrices which at present is notoriously difficult due to very dilute concentrations of NO in blood. Lindsey earned her Bachelor of Science degree in Integrated Science and Technology from James Madison University (2006) and MS in Biotechnology from Johns Hopkins University (2009).

Stephen Rogers, PhD - post doctoral fellow

Stephen is a post-doctoral research associate in Pediatrics. He is working with Allan Doctor, MD, Director of Critical Care Medicine, to identify the mechanism(s) via which the signaling molecule nitric oxide supports red blood cell defense systems, protecting against chemical attack. Their work may lead to novel strategies for manipulating red blood cell metabolism, which could avoid lung injury in children with severe inflammation. Rogers’ work is sponsored by the Children's Discovery Institute, in the Pediatric Pulmonary Disease Center. Dr. Rogers earned a PhD in biochemistry from Cardiff University in Wales, UK in 2006. In 2007 he was invited to join Washington University School of Medicine as a postdoctoral research associate to pursue his interest in red blood cell mediated vasodilation.

Brett Olsen - PhD student - Biochemistry

Brett is a PH.D. student in the Biochemistry and Molecular Biophysics program at WUSM. He is working on a computational model (flux balance analysis) of linked nitric oxide and energy metabolism in red blood cells. This modeling project is in collaboration with the Baker Lab at the WU Center for Computational Biology.

Tara Neumayr, MD - clinical fellow

Tara is a fellow in Pediatric Critical Care and Pediatric Nephrology who is working in the Doctor Lab to help to characterize vascular responses to hypoxia in patients with oxidative stress injury to red blood cells, such as that seen in chronic kidney disease. It is hoped that this work will ultimately lead to novel therapies which will help to ameliorate the high mortality rate of critically ill patients with renal injury. Tara received her undergraduate degree from Duke University in 1999 and her MD from the University of South Dakota in 2003; she completed a pediatrics residency at the Mayo Clinic in 2006 prior to beginning her fellowship at Washington University in the summer of 2006. She is married to Rob Neumayr, who is completing a fellowship in adult cardiology at St. Louis University.

Laura Miller-Smith, MD - clinical fellow

Laura is a fellow in Pediatric Critical Care Medicine. She is using the isolated perfused mouse lung model to characterize the effects of elastin haploinsufficiency on pulmonary vascular physiology. This work is done in collaboration with Dr. Bob Mecham, and will hopefully lead to a better understanding of the vascular pathology seen in William’s Syndrome. Laura's research is sponsered by the Pediatric Scientist Development Program. Laura completed her undergraduate and medical school training at the University of Missouri – Columbia. She then came to St. Louis Children’s Hospital for her pediatric residency and chief resident year. She is married and has an adorable little boy.

Daniella Corcuera - student

Daniella is an undergraduate student in the School of Engineering Class of 2011 at Washington University in St. Louis. She is currently working in the Doctor Lab with Stephen Rogers to characterize the mode of glucose metabolism across a range of oxygen saturations in red blood cells. Their work could provide therapeutic implications that will be useful for medical conditions characterized by arteria hypoxia. Corcuera's work has been sponsored by the Children's Discovery Institute as well as the Howard Hughes Medical Institute through the WU SURF program.

Dylan McLaughlin - student

Dylan is an undergraduate student in the Arts and Sciences Class of 2011 at Washington University in St. Louis. He is currently working in the Doctor Lab with Stephen Rogers to investigate the nitric oxide pathway within glucose metabolism of hypoxic red blood cells. Their work could further the understanding of the role of nitric oxide in hypoxic conditions and provide medical methods useful for conditions of hypoxia. Dylan comes to St. Louis from the Washington, D.C. area.

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