Green Lab


Figure legend: APOBEC3 enzymes deaminate cytosine bases in single-stranded DNA. APOBEC activity on viral genomes results in mutations, degradation of the genome, and restricted infection. The cost of encoding these potent DNA mutators as viral defenses is the potential for activity on the cellular genome where APOBECs can act on ssDNA substrates leading to somatic mutations and DNA damage which compromise genome integrity.


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