Welcome to the Horani lab

Our lab studies airway and motile cilia biology and investigates the effects of mutations on cilia function.

The airway is lined with microscopic, hair-like structures called cilia that sweep the airway in a rhythmic motion. Cilia are essential in defending the airway from infection and injury.

Cilia on nasal cells beat to move mucus along the airway in this video. People whose cilia don’t beat suffer repeated lung, ear and sinus infections.

Cilia dysfunction causes significant disease as evidenced by the genetic syndrome, primary ciliary dyskinesia (PCD). PCD is the prototype of inherited motile ciliopathy, though secondary dysfunction of cilia can occur in common conditions such as asthma, COPD and may contribute to idiopathic bronchiectasis.

Other types of cilia — sensory or primary cilia — are important for other cellular functions and are related to conditions such as kidney disease, hearing loss and blindness.

Photo of cultured airway cells, with motile cilia shown in green and ZO-1 showing cell borders in red.
Photo of cultured airway cells, with motile cilia shown in green and ZO-1 showing cell borders in red.

The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.

Interested in joining us…

We are always looking for enthusiastic people who would like to work on motile cilia and airway biology.