Horani Lab

The airway is lined with microscopic, hair-like structures called cilia that sweep the airway in a rhythmic motion, and are essential in defending the airway from infection and injury. Ciliated cell dysfunction causes significant disease as evidenced by the genetic syndrome, primary ciliary dyskinesia (PCD). PCD is the prototype of inherited motile ciliopathy, though acquired airway diseases may have abnormal cilia. Short, morphologically defective cilia, or slow ciliary beating are observed in chronic obstructive pulmonary disease (COPD), severe asthma, and idiopathic bronchiectasis. Moreover, mutations in motile cilia were linked to idiopathic scoliosis, emphasizing the involvement of cilia in a wide range of conditions.The Horani lab works closely with the Brody’s lab and airway epithelial cell core, and its research focuses on airway epithelial cell differentiation and regulation, with special interest in cilia assembly and how it relates to impaired mucociliary clearance biology in primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells, and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.

The Brody and Horani labs are looking for talented technicians and post-doctorate associates. Please contact us at Horani_a@wustl.edu or BrodyS@wustl.edu

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