Monique Heitmeier, Lab Manager

Monique is utilizing HIV protease inhibitors that inhibit GLUT1 and/or GLU4 as pharmacological tools to determine how altered glucose homeostasis affects disease pathogenesis in mouse models of heart failure and cancer. Current efforts are focused on determining whether altered glucose metabolism affects the unfolded protein/ER stress response in these models, and how modulation of these pathways impacts the observed phenotype.

Rich Hresko, Senior Scientist

Rich is investigating structure/function relationships in GLUT1 and GLUT4. He is utilizing state-of-the-art methodologies to perform solution-state structural analysis. A major focus of his current work is to identify and characterize GLUT4 interacting proteins that may regulate the activity and/or cellular trafficking of glucose transporters.

Maria Payne, Research Assistant

Maria has extensive experience in metabolic measurements in rodents. She is assisting in a number of studies aimed at determining the effects of altered glucose homeostasis on cardiac function. Her current efforts include the study of beneficial effects of incretin hormones in the failing heart.

Thomas Kraft, Graduate Student

Thomas is working on solution-state structural analysis of facilitative glucose transport proteins. He is developing novel methodologies for the stable expression and purification of GLUTs. His research is currently funded by a grant from the Children’s Discovery Institute

Former Lab Members

Laura Silbermann, Visiting Researcher, Germany

Arpita Vyas, MD Senior Clinical Fellow

Dennis Woo, Student

Constanze Haufe, Visiting Scientist, Germany

John Paul Shen, Student, Medical Student

David Kraus, Research Technician

Christal Baird, Research Technician

Jeremy Etzkorn, Medical Student

Helena Jonnson, MSTP Student

Heidi Struthers

Randy Colvin

Paul Buske

Jan Freiss

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