Monique Heitmeier, Lab Manager
Monique is utilizing HIV protease inhibitors that inhibit GLUT1 and/or GLU4 as pharmacological tools to determine how altered glucose homeostasis affects disease pathogenesis in mouse models of heart failure and cancer. Current efforts are focused on determining whether altered glucose metabolism affects the unfolded protein/ER stress response in these models, and how modulation of these pathways impacts the observed phenotype.
Rich Hresko, Senior Scientist
Rich is investigating structure/function relationships in GLUT1 and GLUT4. He is utilizing state-of-the-art methodologies to perform solution-state structural analysis. A major focus of his current work is to identify and characterize GLUT4 interacting proteins that may regulate the activity and/or cellular trafficking of glucose transporters.
Maria Payne, Research Assistant
Maria has extensive experience in metabolic measurements in rodents. She is assisting in a number of studies aimed at determining the effects of altered glucose homeostasis on cardiac function. Her current efforts include the study of beneficial effects of incretin hormones in the failing heart.
Thomas Kraft, Graduate Student
Thomas is working on solution-state structural analysis of facilitative glucose transport proteins. He is developing novel methodologies for the stable expression and purification of GLUTs. His research is currently funded by a grant from the Children’s Discovery Institute
Former Lab Members
Laura Silbermann, Visiting Researcher, Germany
Arpita Vyas, MD Senior Clinical Fellow
Dennis Woo, Student
Constanze Haufe, Visiting Scientist, Germany
John Paul Shen, Student, Medical Student
David Kraus, Research Technician
Christal Baird, Research Technician
Jeremy Etzkorn, Medical Student
Helena Jonnson, MSTP Student