Publications

Selected Publications

1. Murata H, Hruz, PW, and Mueckler M: The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy J. Biol. Chem. 2000; 275: 20251-20254 [ pubmed ]

2. Murata H, Hruz PW and Mueckler, M: Indinavir inhibits the glucose transporter GLUT4 at physiologic concentrations AIDS 2002; 16(6):859-863 [ pubmed ]

3. Hruz PW, Murata H, Qiu H, and Mueckler M: Indinavir induces acute and reversible peripheral insulin resistance in rats. Diabetes 2002; 51: 937-942 [ pubmed ]

4. Koster JC, Remidi M.S., Qiu H, Nichols C and Hruz PW: HIV Protease Inhibitors Acutely Impair Glucose-Stimulated Insulin Release Diabetes 2003: 52(7): 1695-1700 [ pubmed ]

5. Hertel J, Struthers H, Baird Horj C, and Hruz PW: A Structural Basis for the Acute Effects of HIV Protease Inhibitors on GLUT4 Intrinsic Activity J Biol Chem. 2004;279(53):55147-52 [ pubmed ]

6. Yan, Q and Hruz, PW: Direct Comparison of the Acute In Vivo Effects of HIV Protease Inhibitors on Peripheral Glucose Disposal. J. Acquired Immune Defic. Syndr., 40(4): 398-403,2005. [ pubmed ]

7. Hruz, PW and Yan, Q. Tipranavir Without Ritonavir Does Not Acutely Induce Peripheral Insulin Resistance in a Rodent Model.  J Acquired Immune Defic. Syndr. 2006, 43(5):624-625. [ pubmed ]

8. Hruz PW, Yan Q, Struthers H and Jay PY, HIV Protease Inhibitors that Block GLUT4 Precipitate Acute, Decompensated Heart Failure in a Mouse Model of Dilated Cardiomyopathy.  FASEB J.  2008; 22(7):2161-2167  [ pubmed ]

Selected Reviews

1. Hruz PW, Murata H and Mueckler M: Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism Am. J. Physiol. 2001; 280: E549-E553 [ pubmed ]

2. Hruz PW and Mueckler M: Structural Analysis of the GLUT1 Facilitative Glucose Transporter Mol. Membr. Biol, 2001; 18(3): 183-193 [ pubmed ]

3. Hruz, PW : Molecular Mechanisms for Altered Glucose Homeostasis in HIV infection. Am. J. Infectious Dis. 2006; 2(3):187-192 [ pubmed ]

4. Hruz PW.  HIV Protease Inhibitors and Insulin Resistance:  Lessons from In Vitro, Rodent and Healthy Human Volunteer Models.  Curr. Opin. HIV AIDS. 2008; (6):660-5.  [ pubmed ]

5. Hruz PW and Yaresheski K Endocrine Disorders in HIV/AIDS The Washington Manual Endocrinology Subspecialty Consult Second Henderson KE, Baranski TJ, Bickel PE, Clutter PE, Clutter WE, McGill JB Lippincott Williams and Wilkins Philadelphia, PA 2008; 321-328