The Magee lab studies the differences between childhood and adult leukemia. Our goal is to understand why children get leukemia when they are not subject to the effects of aging, environmental exposures and inflammation that can contribute to malignancies in adults. We are using mice to model the effects of different infant and adult leukemia-causing mutations at different ages. We have discovered that mutations have different effects on gene expression, and ultimately cell fate, at different stages of life. We are now working to decode the interactions between mechanisms that regulate development of the blood system and the mutations that cause leukemia. These studies will ultimately lead to new treatments for childhood and adult leukemia.