Work in our lab focuses on understanding the physiologic basis for brain injury in neonates as well as the development of new methodologies for prediction of neurologic injury. The ultimate goal of these efforts is the development of new strategies for neonatal neuroprotection. Our lab group is a multi-disciplinary team of Neonatologists, Neurologists, Pharmacists, Students (high school, undergraduate and medical), and Research Support Staff. We are housed in the Patient Oriented Research Unit on the 10th floor of the Northwest Tower on the Washington University Medical Center Campus.
Currently we use large multimodality (NIRS, EEG, MRI) datasets to develop new approaches to understanding the pathophysiology of both preterm (intraventricular hemorrhage, white matter injury) and term (hypoxic-ischemic encephalopathy) forms of brain injury as well as seizures in all neonates. We continue to recruit new patients for observational and clinical trials. We also are collaborators for Phase II and III of the multi-center HEAL trial, with Washington University serving as the imaging core. Visit our Projects page for more information.
Our core areas of research include:
- Cerebral Autoregulation
- Transitional Hemodynamics of the Preterm Infant
- EEG Analysis and Neonatal Seizures
- Hypoxic-ischemic Encephalopathy
- Applications of MR Imaging in the Newborn
- Advances in Neuroprotection
- Cerebellar Hemorrhage
- Intraventricular Hemorrhage
- Retinopathy of Prematurity