Publications

Our lab has published book chapters and manuscripts across an array of neonatal neuroscience topics, aligned with our research priorities including:

  • Cerebral Autoregulation
  • Transitional Hemodynamics of the Preterm Infant
  • EEG Analysis and Neonatal Seizures
  • Hypoxic-ischemic Encephalopathy
  • Applications of MR Imaging in the Newborn
  • Cerebellar Hemorrhage
  • Intraventricular Hemorrhage
  • Anemia of Prematurity
  • Retinopathy of Prematurity
  • Neonatal Opioid Withdrawal Syndrome/
    Neonatal Abstinence Syndrome
  • Advances in Neuroprotection
  • Neonatal-Perinatal Medicine

Featured Publications

Treating EEG Seizures in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial
Srinivasakumar, Zempel, Trivedi, Wallendorf, Rao, Smith, Inder, Mathur

Published in Pediatrics

Conclusion: In neonates with HIE, EEG monitoring and treatment of electrographic seizures results in significant reduction in seizure burden. Seizure burden is associated with more severe brain injury and significantly lower performance scores across all domains on developmental testing.


Click to download PDF

Early Electrographic Seizures, Brain Injury, and Neurodevelopmental Risk in the Very Preterm Infant
Vesoulis, Inder, Woodward, Buse, Vavasseur, Mathur

Published in Pediatric Research

Conclusion: In preterm infants born before 28 weeks gestation, seizures during the first 3 days after birth are common and are associated with an increased risk of IVH, WMI, and death. Seizure burden was also associated with poorer early language development.


Click to download PDF

A Novel Method for Assessing Cerebral Autoregulation in Preterm Infants Using Transfer Function Analysis
Vesoulis, Liao, Trivedi, El Ters, Mathur

Published in Pediatric Research

Conclusion: This preliminary report suggests an impairment in cerebrovascular autoregulatory dampening ability associated with immaturity, decreased birth weight z-score, and African-American race. Decreased dampening is also associated with IVH, although these results cannot distinguish between decreased dampening as an antecedent or sequela of IVH.


Click to download PDF

All publications 2008-present

Manuscipts
55
Review Articles
4
Book Chapters
5
Total
64

Cerebral Autoregulation of the Neonate

  1. Vesoulis ZA, Liao SM, Mathur AM. Delayed cord clamping is associated with improved dynamic cerebral autoregulation and decreased incidence of intraventricular hemorrhage in preterm infants. J Appl Physiol (1985). 2019 May 2. PubMed PMID: 31046516.
  2. Vesoulis ZA, Liao SM, Mathur AM. Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury: a pilot study. Physiol Meas. 2018 Dec 7;39(12):125004. PubMed PMID: 30270845.
  3. Vesoulis ZA, Liao SM, Mathur AM. Gestational age-dependent relationship between cerebral oxygen extraction and blood pressure. Pediatr Res. 2017 Dec;82(6):934-939. PubMed PMID: 28902182.
  4. Vesoulis ZA, Liao SM, Trivedi SB, Ters NE, Mathur AM. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016 Mar;79(3):453–459. PMCID: PMC4821724.
  5. Liao SM-C, Rao R, Mathur AM. Head Position Change Is Not Associated with Acute Changes in Bilateral Cerebral Oxygenation in Stable Preterm Infants during the First 3 Days of Life. Am J Perinatol. 2015 Jun;32(7):645–652. PMCID: PMC4624398

Blood Pressure & Transitional Hemodynamics of the Preterm Infant

  1. Vesoulis ZA, Hao J, McPherson C, El Ters NM, Mathur AM. Low-frequency blood pressure oscillations and inotrope treatment failure in premature infants. J Appl Physiol (1985). 2017 Jul 1;123(1):55-61. PubMed PMID: 28428252.
  2. Rhoades JS, Bierut T, Conner SN, Tuuli MG, Vesoulis ZA, Macones GA, Cahill AG. Delayed Umbilical Cord Clamping at <32 Weeks' Gestation: Implementation and Outcomes.  Am J Perinatol. 2017 Sep;34(11):1048-1053.  PubMed PMID: 28561189.
  3. Vesoulis ZA, Rhoades J, Muniyandi P, Conner S, Cahill AG, Mathur AM. Delayed Cord Clamping and Inotrope Use in Preterm Infants. J Matern Fetal Neonatal Med. 2018 May;31(10):1327-1334. doi: 10.1080/14767058.2017.1315663. PubMed PMID: 28372510.
  4. Vesoulis ZA, Ters NE, Foster A, Trivedi SB, Liao SM, Mathur AM. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016 Jun;36(6):453–458. PMCID: PMC4882223
  5. Vesoulis ZA, El Ters NM, Wallendorf M, Mathur AM. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2016 Apr;36(4):291–295. PMCID: PMC4808440

EEG Analysis and Seizures

  1. Vesoulis ZA, Gamble PG, Jain S, El Ters NM, Liao SM, Mathur AM. WU-NEAT: A clinically validated, open-source MATLAB toolbox for limited-channel neonatal EEG analysis. arXiv preprint arXiv:180504566. 2018.
  2. El Ters NM, Mathur AM, Jain S, Vesoulis ZA, Zempel JM. Long term electroencephalography in preterm neonates: Safety and quality of electrode types. Clin Neurophysiol. 2018 Jul;129(7):1366-1371. PubMed PMID: 29729590.
  3. El Ters NM, Vesoulis ZA, Liao SM, Smyser CD, Mathur AM. Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants. Early Hum Dev. 2018 Apr;119:68-72. PubMed PMID: 29579560.
  4. El Ters NM, Vesoulis ZA, Liao SM, Smyser CD, Mathur AM. Impact of brain injury on functional measures of amplitude-integrated EEG at term equivalent age in premature infants. J Perinatol. 2017 Aug;37(8):947-952. PubMed PMID: 28492522.
  5. Jain SV, Mathur A, Srinivasakumar P, Wallendorf M, Culver JP, Zempel JM. Prediction of Neonatal Seizures in Hypoxic-Ischemic Encephalopathy Using Electroencephalograph Power Analyses. Pediatr Neurol. 2017 Feb;67:64-70.e2. PubMed PMID: 28062149.
  6. Jain SV, Zempel JM, Srinivasakumar P, Wallendorf M, Mathur A. Early EEG power predicts MRI injury in infants with hypoxic-ischemic encephalopathy.  J Perinatol. 2017 May;37(5):541-546. PubMed PMID: 28206999.
  7. Vesoulis ZA, McPherson C, Neil JJ, Mathur AM, Inder TE. Early High-Dose Caffeine Increases Seizure Burden in Extremely Preterm Neonates: A Preliminary Study. J Caffeine Res. 2016 Sep 1;6(3):101-107. PubMed PMID: 27679737; PubMed Central PMCID: PMC5031091.
  8. Vesoulis ZA, Paul RA, Mitchell TJ, Wong C, Inder TE, Mathur AM. Normative amplitude-integrated EEG measures in preterm infants. J Perinatol. 2015 Jun;35(6):428–433. PMCID: PMC4447544
  9. Srinivasakumar P, Zempel J, Trivedi S, Wallendorf M, Rao R, Smith B, Inder T, Mathur AM. Treating EEG Seizures in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial. Pediatrics. 2015 Nov;136(5):e1302–1309. PMID: 26482675
  10. Vesoulis ZA, Inder TE, Woodward LJ, Buse B, Vavasseur C, Mathur AM. Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014 Apr;75(4):564–569. PMCID: PMC3961524
  11. Srinivasakumar P, Zempel J, Wallendorf M, Lawrence R, Inder T, Mathur A. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013 Aug;163(2):465–470. PMID: 23452588
  12. Mathur AM, Morris LD, Teteh F, Inder TE, Zempel J. Utility of prolonged bedside amplitude-integrated encephalogram in encephalopathic infants. Am J Perinatol. 2008 Nov;25(10):611–615. PMID: 18841534

Hypoxic-Ischemic Encephalopathy

  1. Dizon MLV, Rao R, Hamrick SE, Zaniletti I, DiGeronimo R, Natarajan G, Kaiser JR, Flibotte J, Lee KS, Smith D, Yanowitz T, Mathur AM, Massaro AN. Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs. BMC Pediatr. 2019 Feb 27;19(1):67. PubMed PMID: 30813933.
  2. Natarajan G, Mathur A, Zaniletti I, DiGeronimo R, Lee KS, Rao R, Dizon M, Hamrick S, Rudine A, Cook N, Smith D, Flibotte J, Murthy K, Massaro A; Children's Hospitals Neonatal Consortium (CHNC). Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy. Pediatr Neurol. 2019 Feb;91:20-26. PubMed PMID: 30559002.
  3. Massaro AN, Wu YW, Bammler TK, MacDonald JW, Mathur A, Chang T, Mayock D, Mulkey SB, van Meurs K, Afsharinejad Z, Juul S. Dried blood spot compared to plasma measurements of blood-based biomarkers of brain injury in neonatal encephalopathy. Pediatr Res. 2019 Jan 19. PubMed PMID: 30661082.
  4. Rao R, Trivedi S, Distler A, Liao S, Vesoulis Z, Smyser C, Mathur AM. Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia. Am J Perinatol. 2019 Jan 4. PubMed PMID: 30609430.
  5. Vesoulis ZA, Liao SM, Rao R, Trivedi SB, Cahill AG, Mathur AM. Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2018 Jul;103(4):F377-F382. PubMed PMID: 28942435.
  6. Vesoulis ZA, Rao R, Trivedi SB, Mathur AM. The effect of therapeutic hypothermia on heart rate variability. J Perinatol. 2017 Jun;37(6):679-683. PubMed PMID: 28383534.
  7. Rao R, Trivedi S, Vesoulis Z, Liao SM, Smyser CD, Mathur AM. Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy. J Pediatr. 2017 Apr;183:37-42. PubMed PMID: 27979578.
  8. Cahill AG, Mathur AM, Smyser CD, Mckinstry RC, Roehl KA, López JD, Inder TE, Macones GA. Neurologic Injury in Acidemic Term Infants. Am J Perinatol. 2017 Jun;34(7):668-675. PubMed PMID: 27926973.
  9. Cahill AG, Macones GA, Smyser CD, López JD, Inder TE, Mathur AM. Umbilical Artery Lactate Correlates with Brain Lactate in Term Infants. Am J Perinatol. 2017 May;34(6):535-540. PubMed PMID: 27788532.
  10. Massaro AN, Murthy K, Zaniletti I, Cook N, DiGeronimo R, Dizon ML, Hamrick SE, McKay VJ, Natarajan G, Rao R, Richardson T, Smith D, Mathur AM; Children's Hospital Neonatal Consortium.. Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia. J Pediatr. 2016 Jun;173:76-83.e1. PubMed PMID: 26995699.
  11. Mathur AM, Smith JR, Donze A. Hypothermia and hypoxic-ischemic encephalopathy: guideline development using the best evidence. Neonatal Netw. 2008 Aug;27(4):271–286. PMID: 18697657

Anemia and Retinopathy of Prematurity

  1. Lust C, Vesoulis Z, Jackups R Jr, Liao S, Rao R, Mathur AM. Early red cell transfusion is associated with development of severe retinopathy of prematurity. J Perinatol. 2019 Mar;39(3):393-400. PubMed PMID: 30459388.
  2. Whitehead HV, Vesoulis ZA, Maheshwari A, Rao R, Mathur AM. Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? J Perinatol. 2018 Aug;38(8):1022-1029. PubMed PMID: 29740185.
  3. Vesoulis ZA, Lust CE, Liao SM, Trivedi SB, Mathur AM. Early hyperoxia burden detected by cerebral near-infrared spectroscopy is superior to pulse oximetry for prediction of severe retinopathy of prematurity. J Perinatol. 2016 Nov;36(11):966-971. PubMed PMID: 27559717; PubMed Central PMCID: PMC5079836

Applications of MR Imaging in the Newborn

  1. Vesoulis ZA, El Ters NM, Herco M, Whitehead HV, Mathur AM. A Web-Based Calculator for the Prediction of Severe Neurodevelopmental Impairment in Preterm Infants Using Clinical and Imaging Characteristics. Children (Basel). 2018 Nov 14;5(11). PubMed PMID: 30441798.
  2. Trivedi SB, Vesoulis ZA, Rao R, Liao SM, Shimony JS, McKinstry RC, Mathur AM. A validated clinical MRI injury scoring system in neonatal hypoxic-ischemic encephalopathy. Pediatr Radiol. 2017 Oct;47(11):1491-1499. PubMed PMID: 28623417.
  3. Leadbetter KZ, Vesoulis ZA, White FV, Schmidt RE, Khanna G, Shimony JS, Mathur AM. The role of post-mortem MRI in the neonatal intensive care unit. J Perinatol. 2017 Jan;37(1):98-103. PubMed PMID: 27654494; PubMed Central PMCID: PMC5215703.
  4. Mathur AM, Neil JJ, Inder TE. Understanding brain injury and neurodevelopmental disabilities in the preterm infant: the evolving role of advanced magnetic resonance imaging. Semin Perinatol. 2010 Feb;34(1):57–66. PMCID: PMC2864915
  5. Mathur AM, Neil JJ, McKinstry RC, Inder TE. Transport, monitoring, and successful brain MR imaging in unsedated neonates. Pediatr Radiol. 2008 Mar;38(3):260–264. PMID: 18175110

Advances in Neuroprotection

  1. Mulkey SB, Ramakrishnaiah RH, McKinstry RC, Chang T, Mathur AM, Mayock DE, Van Meurs KP, Schaefer GB, Luo C, Bai S, Juul SE, Wu YW. Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome. J Pediatr. 2017 Jul;186:196-199. PubMed PMID: 28456387.
  2. Rao R, Trivedi S, Vesoulis Z, Liao SM, Smyser CD, Mathur AM. Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy. J Pediatr. 2017 Apr;183:37-42. PubMed PMID: 27979578.
  3. Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016 Jun;137(6). pii: e20160191. PubMed PMID: 27244862.

Cerebellar Hemorrhage

  1. Vesoulis ZA, Herco M, El Ters NM, Whitehead HV, Mathur A. Cerebellar hemorrhage: a 10-year evaluation of risk factors. J Matern Fetal Neonatal Med. 2019 Mar 1:1-9. PubMed  PMID: 30821542.
  2. Vesoulis ZA, Herco M, Mathur AM. Divergent risk factors for cerebellar and intraventricular hemorrhage. J Perinatol. 2018 Mar;38(3):278-284. PubMed PMID: 29242571.

Intraventricular Hemorrhage

  1. Vesoulis ZA, Flower AA, Zanelli S, Rambhia A, Abubakar M, Whitehead HV, Fairchild KD, Mathur AM. Blood pressure extremes and severe IVH in preterm infants. Pediatr Res. 2019 Oct 2. doi: 10.1038/s41390-019-0585-3. [Epub ahead of print] PubMed PMID: 31578033.
  2. Vesoulis ZA, Bank RL, Lake D, Wallman-Stokes A, Sahni R, Moorman JR, Isler JR, Fairchild KD, Mathur AM. Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants. J Perinatol. 2019 Jan;39(1):48-53. PubMed PMID: 30267001.
  3. Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, Strahle JM, Olsen MA, Limbrick DD Jr. Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. Childs Nerv Syst. 2018 Jul 9. PubMed PMID: 29987373.
  4. Han RH, Berger D, Gabir M, Baksh BS, Morales DM, Mathur AM, Smyser CD, Strahle JM, Limbrick DD Jr. Time-to-event analysis of surgically treated posthemorrhagic hydrocephalus in preterm infants: a single-institution retrospective study. Childs Nerv Syst. 2017 Nov;33(11):1917-1926. PubMed PMID: 28884229.
  5. Srinivasakumar P, Limbrick D, Munro R, Mercer D, Rao R, Inder T, Mathur A. Posthemorrhagic ventricular dilatation-impact on early neurodevelopmental outcome. Am J Perinatol. 2013 Mar;30(3):207–214. PMID: 228989930

Neonatal Abstinence Syndome/Neonatal Opioid Withdrawal Syndrome

  1. Vesoulis ZA, Lust CE, Cohlan BA, Liao SM, Mathur AM. Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal Syndrome. J Addict Med. 2019 May 28. PubMed PMID:
    31149915

Ductus Arteriosus Physiology

  1. McPherson C, Luecke CM, Liviskie CJ, Zeller BN, Vesoulis ZA. Acetaminophen Serum Concentrations in Infants Treated Intravenously for Patent Ductus Arteriosus. J Pediatr Pharmacol Ther. 2019 Mar-Apr;24(2):134-137. PubMed PMID: 31019406.
  2. Luecke CM, Liviskie CJ, Zeller BN, Vesoulis ZA, McPherson C. Acetaminophen for Patent Ductus Arteriosus in Extremely Low-Birth-Weight Neonates. J Pediatr Pharmacol Ther. 2017 Nov-Dec;22(6):461-466. PubMed PMID: 29290747.

Neonatal-Perinatal Medicine

  1. Cahill AG, Srinivas SK, Tita ATN, Caughey AB, Richter HE, Gregory WT, Liu J, Woolfolk C, Weinstein DL, Mathur AM, Macones GA, Tuuli MG. Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery Among Nulliparous Women  Receiving Neuraxial Analgesia: A Randomized Clinical Trial. JAMA. 2018 Oct 9;320(14):1444-1454. PubMed PMID: 30304425.

Review Papers

  1. Vesoulis ZA, Mathur AM. Cerebral Autoregulation, Brain Injury, and the Transitioning Premature Infant. Front Pediatr. 2017 Apr 3;5:64. eCollection 2017. Review. PubMed PMID: 28421173
  2. Liao SM, Culver JP. Near infrared optical technologies to illuminate the status of the neonatal brain. Curr Pediatr Rev. 2014;10(1):73–86. PMID: 25055866
  3. Vesoulis ZA, Mathur AM. Advances in management of neonatal seizures. Indian J Pediatr. 2014 Jun;81(6):592–598. PMCID: PMC4338003
  4. Tao JD, Mathur AM. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010 Oct;30 Suppl:S73–81. PMID: 20877412

Book Chapters

  1. Lee S, Mathur AM (2019). Neonatal Seizures. Jain L, Suresh G (Eds.), Clinical Guidelines in Neonatology. New York NY: McGraw Hill Education.
  2. Morris H, Mathur AM (2019). Hypoxic-ischemic encephalopathy. Jain L, Suresh G (Eds.), Clinical Guidelines in Neonatology. New York NY: McGraw Hill Education.
  3. El Ters NM, Lee S, Mathur AM (2019).  Amplitude-integrated EEG.   Ramasethu, J (Ed.)MacDonald's Atlas of Procedures in Neonatology. Philadelphia, PA: Lippincott Williams & Wilkins.
  4. Whitehead HV, Mathur AM (2017). Chapter 62: Neonatal Fluid and Electrolyte Management. Handbook of Neonatology (pp 597-607). New Delhi, India: Indian Journal of Pediatrics.
  5. Vesoulis ZA, Mathur AM (2015). Advances in the Management of Neonatal Seizures. Advances in Neonatology (pp 100-113). New Delhi, India: Indian Journal of Pediatrics.
© 2019 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130