Dickson Lab
Patricia Dickson, MD
The Dickson laboratory studies the mucopolysaccharidosis (MPS) disorders, which are lysosomal enzyme deficiencies affecting the catabolism of glycosaminoglycans. Central nervous system manifestations include progressive intellectual disability, communicating hydrocephalus, dysmyelination, spinal cord compression, and cortical atrophy. Our lab studies cerebrospinal fluid delivery of recombinant enzymes to treat central nervous disease due to MPS, and has demonstrated biodistribution of intrathecally-delivered recombinant enzymes throughout the neuroaxis of MPS models, with correction of lysosomal storage. The laboratory also studies neuroimaging and neuropathology of white matter in MPS brain and the humoral immune responses to therapeutic enzymes. Projects range from bench to bedside including clinical trials.
Keywords: mucopolysaccharidosis, intrathecal, glycosaminoglycan, heparan sulfate, dermatan sulfate, Hurler, Scheie, Sanfilippo, CNS therapeutics, lysosomal storage
Other affiliations
Principal Investigator
Patricia I. Dickson, MD
Centennial Professor of Pediatrics and Genetics
Division Director, Genetics and Genomic Medicine
- Phone: 314-454-6093
Recent Publications
Impaired Mitophagy in Sanfilippo A mice Causes Hypertriglyceridemia and Brown Adipose Tissue Activation
June 21, 2022
Tillo M, Lamanna WC, Dwyer CA, Sandoval DR, Pessentheiner AR, Al-Azzam N, Sarrazin S, Gonzales JC, Kan SH, Andreyev AY, Schultheis N, Thacker BE, Glass CA, Dickson PI, Wang RY, Selleck SB, Esko JD, Gordts PLSM. Impaired Mitophagy in Sanfilippo A mice Causes Hypertriglyceridemia and Brown Adipose Tissue Activation. J Biol Chem. 2022 Jun 21:102159. doi: 10.1016/j.jbc.2022.102159. Epub ahead of print. PMID: 35750212.
Diagnostic yield of exome sequencing in congenital vertical talus
June 1, 2022
Tayebi N, Charng WL, Dickson PI, Dobbs MB, Gurnett CA. Diagnostic yield of exome sequencing in congenital vertical talus. Eur J Med Genet. 2022 Jun;65(6):104514. doi: 10.1016/j.ejmg.2022.104514. Epub 2022 Apr 27. PMID: 35487415.
From karyotypes to precision genomics in 9p deletion and duplication syndromes
December 24, 2021
Sams EI, Ng JK, Tate V, Claire Hou YC, Cao Y, Antonacci-Fulton L, Belhassan K, Neidich J, Mitra RD, Cole FS, Dickson P, Milbrandt J, Turner TN. From karyotypes to precision genomics in 9p deletion and duplication syndromes. HGG Adv. 2021 Dec 24;3(1):100081. doi: 10.1016/j.xhgg.2021.100081. PMID: 35047865; PMCID: PMC8756500.
Neuropathology of murine Sanfilippo D syndrome
December 1, 2021
Takahashi K, Le SQ, Kan SH, Jansen MJ, Dickson PI, Cooper JD. Neuropathology of murine Sanfilippo D syndrome. Mol Genet Metab. 2021 Dec;134(4):323-329. doi: 10.1016/j.ymgme.2021.11.010. Epub 2021 Nov 24. PMID: 34844863.
Neuropathology of murine Sanfilippo D syndrome
September 1, 2021
Hurt SC, Dickson PI, Curiel DT. Mucopolysaccharidoses type I gene therapy. J Inherit Metab Dis. 2021 Sep;44(5):1088-1098. doi: 10.1002/jimd.12414. Epub 2021 Jul 9. PMID: 34189746; PMCID: PMC8525653.
Complete bibliography
Contact Us
Principal Investigator
Patricia Dickson, MD
Phone: 314-454-6093
Email: pdickson@wustl.edu
U.S. mail
Dickson Lab
Department of Pediatrics | Genetics & Genomic Medicine
Washington University School of Medicine
660 S. Euclid Ave.
MSC 8116-0043-02
St. Louis, MO 63110