Nicole is a Staff Scientist who began in the lab in 2002 when we were still back in Boston. Nicole is working on the mechanisms by which phosphodiesterase 4A1 regulates brain tumor growth.
Sara Taylor, PhD
Sara is a Staff Scientist who is using the three-dimensional model of the perivascular stem cell niche to study the actions of novel therapeutics as part of our efforts to develop new treatments for brain tumors.
Najla Kfoury, PhD
Najla is a post-doctoral fellow studying the molecular basis for sex differences in glioblastoma. Her focus is how the normal epigenetics of sexual differentiation interact with the abnormal epigenetics of brain tumors to produce cell intrinsic sex differences in brain tumor biology.
Tao Sun, PhD
Tao is Staff Scientist who first described sex differences in male and female pre-neoplastic astrocytes. Tao continues to study sex differences in the p53 and Rb pathways.
Inema is an MSTP student who is studying the effect of brain tumor growth on cognition in mouse models of glioblastoma. In his work he is using cells engineered to grow invasively and non-invasively and functional connectivity imaging.
Former Lab Members
Karen Gauvain, MD
Post-doctoral fellow (2004-2006) who investigated mechanisms of tumor angiogenesis. Karen is now an Assistant Professor Pediatrics in the Division of Pediatric Hematology/Oncology, Washington University School of Medicine.
David Limbrick, MD, PhD
Post-doctoral fellow (2006-2007) who developed methodologies for the delivery of conformal radiation therapy to mice bearing intracranial tumors. With this he investigated the combined action of PDE4 blockade and radiation therapy in the treatment of a GBM model. Dave is now an Assistant Professor of Neuro-Surgery, Washington University School of Medicine.
Shyam Rao, MD, PhD
Post-doctoral fellow (2008-2010) who developed a three-dimensional in vitro model of the glioblastoma perivascular stem cell niche. We have utilized this model system for multiple purposes including biological studies and compound library screening. Shyam is now an Assistant Professor of Radiation Oncology at The University of California, Davis Cancer Center.
Lihua Yang, MD, PhD
Post-doctoral fellow (2004-2010) who studies the role of CXCR4 and cAMP suppression in the cerebellar development and medulloblastoma. Lihua is now a Staff Scientist in Dr. Mark Miller’s lab at Washington University School of Medicine.
Stacey Ward, PhD
Post-doctoral fellow (2010-2015) who investigated functional interactions between the sonic hedgehog and CXCR4 pathways during cerebellar development and in medulloblastoma. Stacey is currently a senior scientist at Sigma Chemical Co. St Louis.
Amy Barone, MD
Post-doctoral fellow (2013-2015) who performed preclinical evaluations of a novel PDE4 inhibitor and combined VEGF and CXCR4 antagonism in intracranial models of glioblastoma. Amy is now a medical officer at The Food and Drug Administration.
Rajarshi Sengupta, PhD
Post-Doctoral fellow (2010-2014) who investigated the role of CXCR4 in medulloblastoma and the regulation of CXCR4 signaling by sonic hedgehog. Raj is now a senior staff scientist in Dr. Robert Heukeroth’s lab at The University of Pennsylvania.
MSTP student (2011-2015) who investigated circadian rhythm in glioblastoma. Emily is now back in medical school.
A PhD student (2010-2014) who developed an algorithm to deconvolute mixed expression profiling data that allowed him to measure reciprocal interactions between glioblastoma cells and brain microvascular endothelial cells. Mike is now a post-doctoral fellow in Dr. Max Wicha’s lab at The University of Michigan.
An MD/MS student (2008-2010) who investigated the role of phosphodiesterase 4A1 in brain tumor growth. Patty is now a clinical fellow in neuro-pathology at the University of California, San Francisco.