Publications

Selected Publications

1. Woerner, B.M., Warrington, N.M., Kung, A.L. Perry, A. & Rubin, J.B.: Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4 specific antibodies Cancer Research 2005 65(24):11392-11399 [ pubmed ]

2. Kieran, M.W., Turner, C. Rubin, J.B., Chi, S., Zimmerman, M., Chordas, C., Klement, G., Laforme, A., Gordon, A., Thomas, A., Neurberg, D., Browder, T. & Folkman, J.: A phase II trial of anti-angiogenic (metronomic) chemotherapy in pediatrics patients with recurrent or progressive cancer. Journal of Pediatric Hematology/Oncology 2005 27(11):573-581

3. Rubin, JB, Kung, AL, Klein, RS, Chan, JA, Sun, Y, Schmidt, K, Kieran, MW, Luster, AD & Segal, RA : A small molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors PNAS 2003: 100(23):13513-8 [ pubmed ]

4. Rubin, JB., Choi, Y & Segal, RA: Cerebellar Proteoglycans Regulate Sonic Hedgehog Responses During Development Development 2002; 129(9):2223-32 [ pubmed ]

5. Klein, RS., Rubin, JB., Gibson, HD., DeHaan, EN., Alvarez-Hernandez, X., Segal, RA. & Luster, AD: SDF-1µ Induces Chemotaxis and Enhances Sonic Hedgehog-Induced Proliferation of Cerebellar Granule Cells Development 2001; 128(11):1971-1981 [ pubmed ]

6. Yang, L, Jackson, E, Woerner, BM, Perry, A, Piwnica-Worms, D & Rubin, JB: Blocking CXCR4-mediated cAMP suppression inhibits brain tumor growth in vivo. Cancer Research (2007). 67:651-8.

7. Warrington, NM, Woerner, BM, Daginakatte, GC, Dasgupta, B, Perry, A, Gutmann, DH & Rubin, JB: Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in Neurofibromatosis type 1. Cancer Res. 2007 Sep 15;67(18):8588-95 [ pubmed ]

8. Goldhoff P, Warrington NM, Limbrick DD Jr., Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB: Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.Clin Cancer Res. 2008 Dec 1;14(23):7717-25 [ pubmed ]

9. Rubin JB: Chemokine signaling in cancer: One hump or two? Semin Cancer Biol. 2009 Apr;19(2):116-22. Epub 2008 Oct 17. [ pubmed - in process ]

Selected Reviews

1. Rubin, JB & Gutmann, D.H.: Neurofibromatosis type 1 - a model for nerrvous system tumour formation? Nature Cancer Reviews 2005 5(7): 557-564 [ pubmed ]

2. Klein, RS & Rubin JB: Immune and Nervous System CXCL12 and CXCR4:Parallel roles in patterning and plasticity Trends in Immunology 2004; 25(6): 306-314

3. Rubin, JB & Rowitch, DH: Medulloblastoma: A problem of developmental biology Cancer Cell 2002; .2(1):7-8 [ pubmed ]

4. Rubin JB: Only in congenial soil: the microenvironment in brain tumorigenesis. Brain Pathol. 2009 Jan;19(1):144-9. Review [ pubmed ]