Brain injury in cardiac arrest is regionally heterogeneous despite a global hypoxic-ischemic insult. What are the determinants of selective vulnerability or resistance to injury in the brain? Dr. Shoykhet's research focuses on understanding how neurons in specific, behaviorally-relevant circuits are affected by hypoxia, ischemia, and reperfusion during development. Using the rodent somatosensory system, Dr. Shoykhet's laboratory employs neurophysiologic recordings in animals, immunohistochemical analyses in stained tissue and behavior paradigms to study the impact of asphyxial cardiac arrest on thalamocortical circuitry and corresponding animal behavior. The long-term goal of the laboratory is to establish the mechanistic basis for selective vulnerability of defined neuronal population to hypoxic-ischemic insult and to employ this knowledge in designing targeted neuroprotective and rehabilitative strategies applicable to human survivors of cardiac arrest.