Kristine Wylie's Lab
The Wylie Lab studies the microbiome, microbial infections, and maternal host response during pregnancy. We have particular interest in the human virome, and we are interested in developing and applying innovative technologies for the study of viral communities, viral dynamics, and host response. We are carrying out in vitro studies to understand herpesvirus and papillomavirus infections during pregnancy. We use microbial genomics, in vitro cell culture, and animal models in our work.
Our recent work demonstrated associations between viral communities in the vagina with preterm birth, which we studied using the ViroCap enrichment method that we developed. We are currently pursuing studies to uncover the mechanisms underlying this association. Our goals are (a) to develop metrics for predicting women at risk for preterm birth, (b) understand the biology of virus-host interactions in pregnancy.