The Magee lab is working to answer several important questions that surround the causes of childhood leukemia. How do childhood leukemias arise from normal blood forming stem cells? How do leukemia cells hijack normal stem cell programs? Why do childhood and adult leukemias have different mutations? Can we identify and target vulnerabilities that are unique to childhood leukemia? To address these questions, we have created novel pediatric leukemia models in mice. With these tools, we have identified normal developmental switches that contribute to childhood leukemia formation, and we are now studying how to modify these switches to prevent leukemia. Furthermore, we have identified mechanisms that cause some children develop leukemia after they receive chemotherapy for an unrelated malignancy, such as a lymphoma or a neuroblastoma. Our studies will ultimately lead to new methods to treat and even prevent childhood leukemia.