Quayle Lab


Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis (Fluid Therapy in DKA): The purpose of this study is to identify an ideal fluid management strategy for children with diabetic ketoacidosis (DKA) through a randomized control trial comparing four fluid treatment protocols. 

The study will compare treatment arms using a comprehensive set of assessments for neurological injury including measurements of subtle neurological dysfunction during DKA treatment and measures of long-term neurocognitive function. These studies will not only allow investigators to determine whether variations in fluid treatment protocols affect acute neurological outcomes of DKA, but also will provide important additional data regarding the impact of DKA and DKA treatment on long-term neurocognitive function in children. 

The study is a PECARN multicenter study with 12 other pediatric hospitals; the project is funded through an NIH grant with the University of Davis, California, the lead site for the study.  

The study is supported at Washington University by Virginia Koors, Research Coordinator, Megan Chan, Research Patient Assistant and 4 part-time undergraduate and post-baccalaureate students.

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