Pediatric Endocrinology & Diabetes

Insulin Mediated Pseudoacromegaly

Insulin Mediated Pseudoacromegaly (IMPA) is an extremely rare disorder of insulin resistance. Patients affected with this condition have high blood sugar, obesity, and very tall stature. Women with this disease often have excessive body hair and irregular menstrual cycles. Patient with IMPA have physical signs of growth hormone excess (gigantism or acromegaly), however their growth hormone levels are normal. However, patients with IMPA have extremely high insulin levels. Therefore, IMPA is classified as an insulin resistance syndrome. Thus far there is no known genetic or molecular cause of this disease.

Most other known genetic insulin resistance syndromes are associated with short stature. However, individuals with IMPA exhibit signs of tall stature and overgrowth. Therefore, it is hypothesized that IMPA results from a downstream defect in insulin signaling. As a result, the glucose lowering ability of insulin is impaired while the growth promoting ability of insulin enhanced.

Our research group is committed to understanding the genetics and molecular biology of IMPA. We believe that this research can help us identify new treatment strategies for diabetes, obesity, and metabolic syndrome. If you believe that you or a relative may have IMPA please consider participating in our patient registry

Click here for the patient registry of insulin mediated pseudoacromegaly page.

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